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Updated: 31 min 16 sec ago

What Causes Hyperammonemia?

Sun, 02/19/2017 - 23:25
Discussion Reye’s syndrome (RS)is named for Dr. Douglas Reye who along with Drs. G. Morgan and J. Baral described encephalopathy and fatty accumulation and degeneration in children in a 1963 Lancet article. RS usually affects children but can occur at all ages. All organs can be affected but the liver and brain are primarily affected causing liver failure and encephalopathy as toxic metabolites (especially ammonia) accumulate, and intracranial hypertension and cerebral edema occurs. As the ammonia levels begin to rise (> 100 mg/dL) patients lose their appetite, have nausea and emesis and mental status changes which includes personality changes, agitation/combativeness, disorientation and insomnia. As the levels continue to rise (150-200 mg/dL) loss of consciousness and seizures ca...

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#MayoClinicRadio Podcast: 2/18/17

Sun, 02/19/2017 - 22:00
Listen: Mayo Clinic Radio 2/18/17 On Mayo Clinic Radio, transplant surgeon Dr. Charles Rosen discusses liver transplant and the importance of organ donation.?Also on the program, Toni Mangskau,?clinical trials referral coordinator at Mayo Clinic?s Cancer Education Center in Rochester, Minnesota, explains how clinical trials are conducted. And gastroenterologist Dr. Michael Camilleri offers prevention tips for [...] (Source: News from Mayo Clinic)
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New Score Predicts Liver Cancer After Transplant New Score Predicts Liver Cancer After Transplant

Wed, 02/15/2017 - 14:44
Adding the MORAL score to Milan criteria identifies new subset of patients at high risk and identifies patients who should not undergo liver transpant with a living donor.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
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New Insights Into Liver Disease and Transplantation New Insights Into Liver Disease and Transplantation

Mon, 02/13/2017 - 16:46
Findings on new therapeutic options, long-term outcomes, and diagnostic tools were on view at the recent Liver Meeting. Dr William Balistreri reports what you need to know most.Medscape Gastroenterology (Source: Medscape General Surgery Headlines)
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[In Brief] News at a glance

Thu, 02/09/2017 - 22:00
In science news around the world, the U.S. Department of Agriculture faces a lawsuit after pulling animal welfare records from its website, a study of liver transplantations revives concerns that China has in the past allowed the use of organs from executed prisoners for transplants, Venezuela faces a shortage of medicines including anti-HIV drugs, a Japanese space probe fails to deploy technology that could help collect space junk, and more. Also, an Iranian-born researcher employed at two European institutes now faces the death penalty in his home country for "espionage." And Massachusetts Institute of Technology students stage a revival of a musical that celebrates the school's campus prank culture, or hacking. (Source: ScienceNOW)
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Dignity Health St. Joseph's forges heart relationship with Los Angeles institute

Tue, 02/07/2017 - 19:23
Dignity Health St Joseph's Hospital and Medical Center is teaming up with Los Angeles-based Cedars-Sinai Heart Institute to provide complex heart procedures at the Phoenix hospital. Under the arrangement, Cedars-Sinai Heart Institute staff will act as mentors so the St. Joseph's transplant team — which includes lung, liver and kidney — can begin offering ventricular assist devices, or VADs. The VAD procedure, which is an extremely complex heart procedure that doctors use at Cedars-Sinai, is… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

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Critically ill children can still undergo liver transplantation and survive

Tue, 02/07/2017 - 04:00
(American College of Surgeons) Advancements in critical care make it possible for even the sickest children to successfully undergo liver transplantation. According to a new study published online as an 'article in press' in the Journal of the American College of Surgeons (JACS), children who are sick enough to require mechanical ventilation or dialysis before transplantation achieve the same survival benefit as children who are stable prior to the surgical procedure. (Source: EurekAlert! - Medicine and Health)
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NSAIDs no better than placebo for spinal pain

Mon, 02/06/2017 - 22:00
No simple analgesics provide clinically important effects over placebo for spinal pain Related items fromOnMedica NSAIDs and COX 2s linked to heart failure admission No role for paracetamol in treating pain in osteoarthritis Exercise better for back pain than acupuncture say experts Liver transplant for paracetamol overdose rates vary widely across Europe Pregnancy paracetamol warning (Source: OnMedica Latest News)
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Even though it's costly, why Largo Medical Center expanded its transplant program

Mon, 02/06/2017 - 11:50
The first recipient of a liver transplant at Largo Medical Center is out of intensive care and recovering well, according to the physician who leads the hospital ’s transplant program. Dr. Hussein Osman-Mohamed, chief of the hospital’s Transplant Institute of Florida, performed the liver transplant in late January, expanding the program the hospital started in 2015 with kidney transplants. Largo Medical Center is the second hospital in the Tampa Bay ar ea to offer liver transplants. Tampa General… (Source: bizjournals.com Health Care:Physician Practices headlines)
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Health Care Special Report: Children ’s Mercy platform targets ‘Goldilocks’ doses

Fri, 02/03/2017 - 10:00
For some treatments, the perfect dose is a necessity. Leukemia patients, for example, take busulfan to prepare for a bone marrow transplant. Too little, and the patient ’s body won’t accept the transplant. Too much, however, can cause irreversible liver damage. “It’s a really fine line,” said Susan Abdel-Rahman, director of the pharmacokinetic and pharmacodynamics core laboratory at Children’s Mercy. She created a platform to help determine how much i s “just right” based on a child’s… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
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Living-donor liver transplant most costly transplant in Japan

Tue, 01/31/2017 - 22:00
(Source: PharmacoEconomics and Outcomes News)

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New Jersey nanny donates part of her liver to save girl

Mon, 01/30/2017 - 22:45
College student Kiersten Miles, 22, from New Jersey, decided to donate part of her liver to the 16-month-old girl she nannies for, Talia Rosko, after learning she would need a transplant or likely die. (Source: the Mail online | Health)
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Lab notes: It's life, Jim, but not as we know it

Fri, 01/27/2017 - 11:42
Things took a turn for the mythological this week with the creation ofa human-pig hybrid, or chimera. It marks the first time that embryos combining two large, distantly-related species have been produced and is a big step towards being able to generate human hearts, livers and kidneys for transplant. And as if pig-humans (or human-pigs, or ... whatever) weren ’t enough, researchers havemodifiedE coli microbes to carry an expanded genetic code. Apparently this will ultimately allow them to be programmed, but also paves the way for the creation and exploitation of entirely new life forms. Given that human interactions with other species tend togo the way of the Cern weasel, this might not be great for whatever emerges, but still. Yay science. Definitely good news for everyone is the possi...
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Strange New World: Scientists Create Human-Pig Embryos

Fri, 01/27/2017 - 03:28
function onPlayerReadyVidible(e){'undefined'!=typeof HPTrack&&HPTrack.Vid.Vidible_track(e)}!function(e,i){if(e.vdb_Player){if('object'==typeof commercial_video){var a='',o='m.fwsitesection='+commercial_video.site_and_category;if(a+=o,commercial_video['package']){var c='&m.fwkeyvalues=sponsorship%3D'+commercial_video['package'];a+=c}e.setAttribute('vdb_params',a)}i(e.vdb_Player)}else{var t=arguments.callee;setTimeout(function(){t(e,i)},0)}}(document.getElementById('vidible_1'),onPlayerReadyVidible); In a chilling experiment seemingly out of science fiction, scientists created two human-pig embryos — then destroyed them after a few weeks of growth. The creations included human stem cells grown inside pig embryos, with the cells constituting only a small part of the embryos. Th...
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First human-pig 'chimera' created in milestone study

Thu, 01/26/2017 - 21:41
Prospect of growing human organs for transplantation raised by creation of first ever embryos combining two large, distantly related speciesScientists have created a human-pig hybrid in a milestone study that raises the prospect of being able to grow human organs inside animals for use in transplants.It marks the first time that embryos combining two large, distantly-related species have been produced. The creation of this so-called chimera – named after the cross-species beast of Greek mythology – has been hailed as a significant first step towards generating human hearts, livers and kidneys from scratch.Continue reading... (Source: Guardian Unlimited Science)

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Scientists take first steps to growing human organs in pigs

Thu, 01/26/2017 - 18:49
Scientists have grown human cells inside pig embryos, a very early step toward the goal of growing livers and other human organs inside animals to transplant into people. (Source: CBC | Health)
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Zimbabwe: Baby Manqoba Back Home After Successful Liver Transplant

Thu, 01/26/2017 - 09:31
[The Herald] Baby Manqoba, the one-year-old girl who became known last year when her parents, with the help of friends, workmates and corporates launched a blitz to raise funds for her liver transport in India, arrived back home in good health last night.Manqoba and her mother Shamiso Yikoniko, who is a journalist, were welcomed at Harare International Airport by friends and family members after the successful liver transplant. (Source: AllAfrica News: Health and Medicine)
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Changing Trends in Liver Transplant Indications Changing Trends in Liver Transplant Indications

Tue, 01/24/2017 - 22:22
Hepatitis C virus (HCV) infection is declining while nonalcoholic steatohepatitis (NASH) and alcoholic liver disease (ALD) are increasing as indications for liver transplant, according to U.S. data.Reuters Health Information (Source: Medscape Transplantation Headlines)
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South Africa: Gugulethu Toddler Needs a Liver Transplant - and a Better House

Tue, 01/24/2017 - 13:26
[News24Wire] One-year-old Siyanda Tafeni needs a liver transplant. But even if a donor can be found quickly, doctors warn that the toddler may not survive the transplant unless he gets a better home, with an inside toilet and running water. (Source: AllAfrica News: Health and Medicine)
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SBRT Equivalent to TACE as Bridge to Transplant for Patients With HCC

Sun, 01/22/2017 - 22:40
Use of stereotactic body radiation therapy (SBRT) was equally effective as transarterial chemoembolization (TACE) as a method of bridge to transplant among patients with hepatocellular carcinoma. (Source: CancerNetwork)

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