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Updated: 1 hour 38 min ago

What Causes Anemia?

Sun, 05/14/2017 - 23:29
Discussion One of the most common problems in pediatrics is anemia. It is defined as “a lower than normal value for the related measurements of hemoglobin, hematocrit, and number of red blood cells”, usually 2 standard deviations below the normal for age. Normal hematological values change with age. For a discussion of which values are used click here. The most common type of anemia in childhood is iron deficiency which is commonly caused by inadequate stores (e.g. premature infant), inadequate intake (e.g. poor nutrition) or blood loss (e.g. menses). Anemia screening is recommended at age 9-12 months, and for adolescent males and females during routine health examinations. As iron deficiency is the most common cause, often a trial of therapeutic iron (2-6 mg/kg/day of element...

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Categories: Publications

New pill spares women trauma of liver transplant

Sat, 05/13/2017 - 20:17
In the UK, 20,000 people – 90 per cent of them women – suffer from primary biliary cholangitis, also known as primary biliary cirrhosis (PBC). (Source: the Mail online | Health)
Categories: Publications

FDA Drug Safety Communication: FDA limits duration and usage of Samsca (tolvaptan) due to possible liver injury leading to organ transplant or death

Fri, 05/12/2017 - 14:04
The U.S. Food and Drug Administration (FDA) has determined that the drug Samsca (tolvaptan) should not be used for longer than 30 days and should not be used in patients with underlying liver disease because it can cause liver injury, potentially requiring liver transplant, or death. (Source: FDA Center for Drug Evaluation and Research - What's New)

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Categories: Publications

Liver Transplant Outcomes Improve Over Time (CME/CE)

Tue, 05/09/2017 - 16:00
(MedPage Today) -- Patient, graft survival higher following introduction of new HCV drugs (Source: MedPage Today Gastroenterology)

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Gene Variation Predicts Recovery in Decompensated Hep C Gene Variation Predicts Recovery in Decompensated Hep C

Sun, 05/07/2017 - 15:46
Genetic differences that are associated with recovery in patients with hepatitis C and decompensated cirrhosis who achieve a sustained virologic response could someday guide liver transplantation.Medscape Medical News (Source: Medscape Medical News Headlines)

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Study: Genetic markers may predict which HCV, cirrhosis patients improve with treatment

Sat, 05/06/2017 - 03:00
This study was presented at Digestive Disease Week ® (DDW) 2017, the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. (Source: EurekAlert! - Medicine and Health)
Categories: Publications

Multiclass HCV Resistance to DAA Failure Multiclass HCV Resistance to DAA Failure

Tue, 05/02/2017 - 03:16
This study aimed to define the pattern of clinically relevant resistance-associated substitutions associated with real-life DAA virological failures.Liver International (Source: Medscape Transplantation Headlines)

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Milestones made possible #becauseofadonor

Mon, 05/01/2017 - 11:58
There are more than 80 children currently waiting for life-saving organ transplants at Boston Children’s Hospital. The Pediatric Transplant Center team is grateful for the donors who give these kids a second chance. Meet Maggie. The 20-year-old received her first double-lung transplant at 4 years old and her second at 7 years old. #becauseofadonor, Maggie is able to go to college. Meet Tom. At 15 years old, he received a liver transplant. #becauseofadonor, Tom, now 22, is able to run the Boston Marathon. Meet Aaron. The 10-year-old received his heart transplant at just 1 year old. #becauseofadonor, Aaron was able to get his black belt in karate. Tell us about your milestone made possible #becauseofadonor. The post Milestones made possible #becauseofadonor appeared first on Th...
Categories: Publications

WATCH: Baby boy finds 'perfect' liver match in godmother

Fri, 04/28/2017 - 16:22
Their emotional meeting after the transplant operation that saved Finn O'Sullivan's life. (Source: ABC News: Health)
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Fecal Transplant Safe for Hepatic Encephalopathy Fecal Transplant Safe for Hepatic Encephalopathy

Thu, 04/27/2017 - 18:19
For the first time, a clinical trial has shown that fecal transplantation can ease the decline in brain function that can result from liver failure; and the effectiveness surprised researchers.Medscape Medical News (Source: Medscape Critical Care Headlines)
Categories: Publications

New progress toward finding best cells for liver therapy

Wed, 04/26/2017 - 12:54
In an important step toward using transplanted cells to treat liver failure, researchers demonstrate successful transplantation of fetal rat liver cells to an injured adult rat liver. (Source: ScienceDaily Headlines)
Categories: Publications

Consumer Health Tips: Liver transplantation

Tue, 04/25/2017 - 23:00
Liver transplant Liver transplantation usually is reserved for people who have significant complications due to end-stage chronic liver disease. In rare cases, sudden failure of a previously normal liver can occur. Learn more about the functions of the liver, the waiting list for available organs, and how to begin the process of signing up to [...] (Source: News from Mayo Clinic)

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NASH: The Next Untapped Pharma Market Gives Investors Many Options NASH: The Next Untapped Pharma Market Gives Investors Many Options

Tue, 04/25/2017 - 19:20
Large drugmakers with piles of cash are on the hunt for promising medicines being developed by small companies to treat non-alcoholic steatohepatitis (NASH), a progressive fatty liver disease poised to become the leading cause of liver transplants by 2020.Reuters Health Information (Source: Medscape Transplantation Headlines)
Categories: Publications

NASH: The next untapped pharma market gives investors many options

Mon, 04/24/2017 - 11:09
(Reuters) - Large drugmakers with piles of cash are on the hunt for promising medicines being developed by small companies to treat NASH, a progressive fatty liver disease poised to become the leading cause of liver transplants by 2020. (Source: Reuters: Health)
Categories: Publications

How Common is α -1-Antitrypsin Deficiency?

Sun, 04/23/2017 - 23:32
Discussion α-1-Antitrypsin Deficiency (A1AT) is a common single-gene mutation disease that is homozygous recessive. The normal allele is called M and the most common abnormal allele is Z. There are other alleles though. The gene codes for one of the primary protease inhibitors in the serum, thus those who are homozygous for the Z gene are sometimes referred to as “PIZZ” or “PIZ.” α-1-Antitrypsin is found in all body tissues but is especially important in the serum and lung. As noted it is one of the primary neutrophil protease inhibitors in the serum, and acts to neutralize these enzymes when they leak into the extracellular fluid during inflammation. The Z mutation causes the synthesis of an abnormal protein which is retained in the hepatocytes and accu...
Categories: Publications

Fecal microbiota transplants improve cognitive impairment caused by severe liver disease

Fri, 04/21/2017 - 11:49
Fecal transplantation of bacteria from one healthy donor into patients that suffer from hepatic encephalopathy, is safe and improves cognitive function compared with standard of care treatment for the condition, new research concludes. The study results also demonstrated that the number of hospitalizations following fecal transplantation plus antibiotics was two, compared to the standard of care arm, which was 11. (Source: ScienceDaily Headlines)
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Treatment of HCV allows for sustained removal from the liver transplant waiting list

Fri, 04/21/2017 - 03:00
(European Association for the Study of the Liver) A new European study presented today demonstrated that patients with chronic HCV and severe liver damage, taken off the liver transplant list as a result of successful DAA therapy, had a favorable outcome over a year later. The study, presented at The International Liver Congress ™ 2017 in Amsterdam, The Netherlands, showed that 26.7 percent of patients could be removed from the waiting list due to clinical improvement. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Fecal microbiota transplants improve cognitive impairment caused by severe liver disease

Fri, 04/21/2017 - 03:00
(European Association for the Study of the Liver) A study presented today found that fecal transplantation of bacteria from one healthy donor into patients that suffer from hepatic encephalopathy, is safe and improves cognitive function compared with standard of care treatment for the condition. Presented at The International Liver Congress ™ 2017 in Amsterdam, The Netherlands, the study results also demonstrated that the number of hospitalizations following fecal transplantation plus antibiotics was two, compared to the standard of care arm, which was 11. (Source: EurekAlert! - Infectious and Emerging Diseases)
Categories: Publications

UAB performs Alabama's first transplant where cadaver liver is 'kept alive' outside body

Thu, 04/20/2017 - 03:00
(University of Alabama at Birmingham) A new clinical trial seeks to determine whether a machine that pumps warm, oxygenated blood in cadaver kidneys outside of the body can improve quality of the organ prior to transplant. (Source: EurekAlert! - Social and Behavioral Science)
Categories: Publications

A life taken. A life given. A life shared.

Wed, 04/19/2017 - 11:17
Kaitlyn and Hannah When she read the article in the Cape Cod Times about the 11-year-old girl who underwent a life-saving liver transplant, Melissa Dunphe knew. “Too many pieces fit for it not to be.” She knew that the child, who was at the same hospital on the same floor on the same day, had to be the one who received her five-year-old daughter Kaitlyn’s liver. Five years earlier, at eight months old, Kaitlyn was in a car accident that left her without the use of her limbs and unable to breathe on her own. During her short life, her parents made moments matter. “She was a very happy child,” her mom Melissa says. “She loved life — going for walks, having her nails painted and going to the beach. “We knew she wouldn’t live long, but I never expected it to be so soon.” Tw...
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