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International Society of Heart and Lung Transplantation International Society of Heart and Lung Transplantation

Wed, 03/29/2017 - 16:53
Read clinically focused news coverage of key developments from ISHLT on Medscape (Source: Medscape Today Headlines)
Categories: Publications

Pioneering stem cell gene therapy cures infants with bubble baby disease

Mon, 03/27/2017 - 19:18
FINDINGSUCLA researchers have developed a stem cell gene therapy cure for babies born with adenosine deaminase-deficient severe combined immunodeficiency, a rare and life-threatening condition that can be fatal within the first year of life if left untreated.In a phase 2 clinical trial led by Dr. Donald Kohn of the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, all nine babies were cured. A 10th trial participant was a teenager at the time of treatment and showed no signs of immune system recovery. Kohn’s treatment method, a stem cell gene therapy that safely restores immune systems in babies with the immunodeficiency using the child’s own c ells, has cured 30 out of 30 babies during the course of several clinical trials.BACKGROUNDAdenosine deam...
Categories: Publications

It Seemed Like Such a Good Idea (Gwen Moritz Editor's Note)

Mon, 03/27/2017 - 12:11
I wish I were as fat as I was the first time I thought I was fat, so something in Senior Editor Mark Friedman’s health column last week jumped out at me: Dr. Bruce Murphy, CEO of the Arkansas Heart Hospital, included artificial sweeteners in a list of factors contributing to the obesity epidemic that led his company to add weight-loss surgery to its menu of services. Last year, The New York Times revealing that, in the 1960s when I was a tot, the sugar industry actually paid researchers “to play down the link between sugar and heart disease and promote saturated fat as the culprit instead.” As a result of this made-to-order science, the American diet shifted to “low-fat, high-sugar foods that some experts now blame for fueling the obesity crisis.” So things we...

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Categories: Publications

Historian: Human History 'Will End When Men Become Gods'

Fri, 03/24/2017 - 13:11
Yuval Noah Harari, an Israeli historian and the internationally best-selling author of Sapiens, has a new book out about the future of humanity, called Homo Deus. He recently sat down with The WorldPost at a Berggruen Institute salon in Los Angeles. In the following interview, he discusses the new authority of “dataism” and godlike powers of science to redesign humanity and create an inorganic, new species ― artificial intelligence. WorldPost: In your previous book, Sapiens, you observed that humans are the only species that can organize themselves around abstract ideas or codes ― myth, religion, ideology. In your new book, Homo Deus, you argue that a new ideology has arisen ― “dataism” ― that is the new organizing principle of humanity. ...
Categories: Publications

How to Boost Your Stem Cells

Thu, 03/23/2017 - 19:28
A California man named Kris Boesen was completely paralyzed after breaking his neck in a terrible car crash last March. But now he can brush his teeth and hug his family again… He's even started to regain sensation in his legs. And it's all because of a simple procedure he underwent about a month after his accident: stem cell therapy. During Kris' procedure, researchers at the University of Southern California injected 10 million stem cells into his spinal cord. Within two weeks, he could wiggle his fingers. Three months later, he was able to feed himself, write his name and operate his wheelchair. His recovery has been nothing short of amazing. Especially when you consider that Kris broke the same part of his spine that "Superman" actor Christopher Reeve broke&#8...
Categories: Publications

Cryogenic preservation: from single cells to whole organs – Science Weekly podcast

Wed, 03/22/2017 - 11:59
Hannah Devlin looks at recent advances in the field ofcryopreservation and asks how close we are to applying these technologies to whole organsSubscribe& Review oniTunes,Soundcloud,Audioboom,Mixcloud&Acast, and join the discussion onFacebook andTwitterLast year, around 3,500 organs were transplanted into patients in the UK alone. That said, a large number of organs were also discarded because the moment a donor dies, doctors have only eight or so hours to find a patient on the organ register who is a match and can be almost immediately ready for surgery. One recent estimate suggested that as many as 60% of the hearts and lungs donated for transplantation are discarded each year. But a new technology could be about to change this: whole-organ cryopreservation.Continue reading... (So...
Categories: Publications

New Score Predicts Adult Heart Transplant Waitlist Mortality New Score Predicts Adult Heart Transplant Waitlist Mortality

Mon, 03/20/2017 - 22:38
A new four-variable score accurately predicts one-year mortality for adults awaiting heart transplant, researchers from France report.Reuters Health Information (Source: Medscape Transplantation Headlines)
Categories: Publications

Who You Should Love After Loss

Mon, 03/20/2017 - 21:39
It’s lonely. In fact, lonely is not a strong enough word to grasp the depth of aloneness that becomes your life after loss. You are desperately and hopelessly alone regardless of how many people surround you, love you, care about you. You can be in the center of a room that is filled with family, friends, and acquaintances and yet it still feels as if you are invisible. It’s as if you are floating above your body not participating in life as you knew it before death knocked at your door and left you reeling from its cold, hard grasp. The loneliness is so extreme that I’ve seen people do anything to avoid it. In fact, I’ve seen myself do anything to avoid it. We run away to corners of the world searching to feel connected and embraced. We numb our pain with artificial...

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Categories: Publications

Family Of Boy Struggling After Heart Transplant Now Losing Home

Mon, 03/20/2017 - 12:37
BOSTON (CBS) — The family of a little boy who is fighting to survive after a heart transplant recently got some more bad news after an already rough year – they found out their home will have to be torn down due to a mold infestation. Five-year-old Ari “Danger” Schultz, who had a congenital heart defect, received a new heart earlier this month at Boston Children’s Hospital after waiting 211 days. But the family is facing new challenges, and says they need help now more than ever. It started with Ari fighting acute rejection after his transplant. “Ari is struggling mightily,” father Mike Schultz wrote on his blog Monday. “He went downhill and needed operations and procedures every day this week. On the day of procedures kids can’t eat. Ari...
Categories: Publications

Weight-Loss Surgery Arrives at Arkansas Heart Hospital

Mon, 03/20/2017 - 04:00
The Arkansas Heart Hospital in Little Rock recently began offering weight-loss surgery as a way to fight heart disease and rising obesity rates in Arkansas. The newly formed Bariatric & Metabolic Institute at the Arkansas Heart Hospital started seeing patients at the first of the year and has had “hundreds of patients” so far, said Dr. Samuel Bledsoe, the director of the institute. After the patients go through the necessary tests and screenings to determine if they are candidates for the weight-loss procedure, Bledsoe said, he estimates that by the summer he’ll be performing between 20 and 40 surgeries a month. The Arkansas Heart Hospital decided to offer the procedures because adult obesity rates have skyrocketed from about 10 percent of the population in Arkansas j...
Categories: Publications

AliveCor raises $30m, launches Kardia Pro platform in U.S.

Thu, 03/16/2017 - 17:41
AliveCor said today that it landed $30 million in a series D funding round and that it released its artificial intelligence-enabled Kardia Pro platform in the U.S. The company’s platform enables doctors to remotely monitor their patients for early signs of atrial fibrillation, a common cardiac arrhythmia. “Heart disease is the No. 1 cause of death in the United States, claiming more lives than all forms of cancer combined. To manage heart disease and stroke risk, leading cardiologists want to see more than just ECGs from their patients,” CEO Vic Gundotra said in prepared remarks. “Kardia Pro tracks important measures of physiology like weight, activity and blood pressure, and, for the first time, AI technology is used to create a personal heart profile for each user, enabling use...
Categories: Publications

Toddler gets special escort for heart transplant in snowstorm

Wed, 03/15/2017 - 03:20
Pennsylvania Gov. Tom Wolf said a 23-month-old safely made the trip between two hospitals some 80 miles apart (Source: Health News:
Categories: Publications

UCLA performed most heart and lung transplants in the United States in 2016

Tue, 03/14/2017 - 16:00
Amanda GriswoldUCLA heart and lung transplants teams. UCLA performed the highest combined number of heart and lung transplants among all U.S. medical centers in 2016, according to United Network for Organ Sharing data, a nonprofit that manages the nation ’s organ transplant system.UCLA ’s thoracic transplant program performed 170 transplants during the 12-month period: 103 adult lung transplants, 58 adult heart transplants and nine pediatric heart transplants, according to UNOS.“This accomplishment is a tribute to our dedicated surgeons, physicians, nurses and allied health care professionals who are open to new challenges,” said Dr. Abbas Ardehali, the program’s surgical director. “We take pride in the innovative nature of our program and look forward to setting n ew standard...

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Categories: Publications

Second opinion for midaortic syndrome gives Cameron a second chance

Tue, 03/14/2017 - 12:30
Cameron Grubb likes to shoot Nerf guns, and even his own doctors aren’t immune from his aim — in fact, they often fire back. It’s a playful act that everyone welcomes, however, particularly since this 6-year-old has defied the odds multiple times in his young life. Just three years ago, Cameron was struggling to survive after being diagnosed with extremely high blood pressure — so elevated, in fact, that his clinicians in Kansas thought the monitor must be broken. When they eventually confirmed the reading, it was 170/140, a dangerous level that sent him to the local intensive care unit for nine days. It wasn’t until months later that he was finally diagnosed with midaortic syndrome, a narrowing of the heart’s largest blood vessel, as well as renovascular hypertension, high blo...
Categories: Publications

Report: The best (and worst) transplant programs in Massachusetts

Sun, 03/12/2017 - 23:39
Six months after beating records for performing the most heart transplants than any other hospital in New England, Tufts Medical Center has earned bragging rights to one of the best transplant programs in the country in a national, annual report. According to data released from the Scientific Registry of Transplant Recipients this year, Tufts Medical Center's heart transplant program was rated a five — or better than expected. The hospital was the only one in Massachusetts to score a five in any… (Source: Health Care:Physician Practices headlines)
Categories: Publications

Tufts Surgeons Perform 2 Double Transplants On Same Day

Thu, 03/09/2017 - 21:34
BOSTON (CBS) – A rare combined series of transplants for two men on the same day, and thanks to the expertise at Tufts Medical Center in Boston, both patients are on the verge of going home. Both men needed heart and kidney transplants, and with those two organs, you can’t transplant one without the other. That’s because without a healthy heart the kidney transplant may fail and vice versa. But what makes this story so unusual is that the organs became available on the same day. So Tufts transplant teams had to go into overdrive. “I had no strength. I wasn’t able to do any of the things I used to do,” says 67-year-old David Horne. “I couldn’t walk up steps. My endurance was going down and down and down and down. I needed help,” says...
Categories: Publications

Here ’s how you heat up cold hearts—for transplantation

Wed, 03/08/2017 - 16:22
[Photo courtesy University of Minnesota]A University of Minnesota–led research team has successfully warmed large-scale animal heart valves and blood vessels that were previously preserved at low temperatures. The discovery of this rewarming process is pivotal for organs and tissues that are left in storage for transplantation for extended periods. “This is the first time that anyone has been able to scale up to a larger biological system and demonstrate successful, fast, and uniform warming hundreds of degrees Celsius per minute of preserved tissue without damaging the tissue,” said John Bischof, a University of Minnesota mechanical and biomedical engineering professor and senior author of the study, in a news release. Researchers have previously only been able to rewarm 1 mm of ti...

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Categories: Publications

Why Diversity Lies at the Heart of Patient-Centric Pharma

Wed, 03/08/2017 - 07:25
Whether understanding a patient pathway, designing a service platform or training staff, patient centricity is, at its core, about the continued desire to improve the patient experience. This requires an understanding of the patient experience for everyone, regardless of gender, sexual orientation, race, religious beliefs, disability, socio-economic background or age.Yet ‘diversity’ is a poorly used word, says Paul Simms, Chairman of eyeforpharma, a term invoked to meet artificial quotas or provide a tick box. “It can be a minimum requirement, something too easily dismissed by conservatives as only of importance to extreme lefties,” he says. “But understan ding patients can only be done properly if we embrace diversity, because our companies must mirror society.”He points to ar...
Categories: Publications

Artificial mouse embryos created

Fri, 03/03/2017 - 16:15
Conclusion This early-stage research offers a good insight into the development of mouse embryos and the sequence of biological steps that take place up to the point of implantation in the womb and immediately afterwards. They could provide an insight into the early stages of human life. However, this does not mean that the creation of artificial human life is now possible: The study was carried out on mice stem cells, which have a very different biological make-up to humans so the processes may not be identical with human cells. While the artificial mouse embryo seemed to behave like a natural one, it is unlikely it could develop to a healthy foetus, as other components – such as the yolk sac that provides nutrition – were missing. Not all embryonic and trophoblast structures de...
Categories: Publications

Researchers successfully thaw cryopreserved tissue with no damage

Thu, 03/02/2017 - 22:17
A group of US scientists have successfully thawed cryopreserved tissue without damage to the sample, a huge step towards being able to use frozen or preserved tissues in transplantation, according to a new study. Researchers out of the University of Minnesota have developed a new heating method, using iron oxide nanoparticles which surround frozen tissues, to uniformly warm frozen animal heart valves without causing harm to the tissue. While cryopreservation of tissue and organs has been possible for some time, thawing the organs and tissue without cracks and fissures forming has been a more difficult task. “This paper takes the first practical step towards making tissue banking a reality,” Science Translational Medicine editor Caitlin Czajka said. Results from the study were ...
Categories: Publications