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Cardiac Surgical Outcomes in Abdominal Solid Organ (Renal and Hepatic) Transplant Recipients: A Case Matched Study

Fri, 11/25/2011 - 01:38
Background: Cardiovascular disease is a common cause of mortality and morbidity after abdominal solid organ transplants (ASOT). We studied the long-term outcomes after cardiac surgery in patients with functioning ASOT and compared them with a case matched (CM) population. (Source: Heart, Lung and Circulation)

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Categories: Publications

University of Texas surgeons first to implant Sapien heart valve

Wed, 11/23/2011 - 17:29
Cardiologists and cardiovascular surgeons at The University of Texas Health Science Center at Houston and Memorial Hermann Heart & Vascular Institute are the first in Houston to implant the artificial heart valve recently approved by the Food and Drug Administration. The Sapien heart valve made by Edwards Lifesciences is implanted through a catheter as an alternative to open heart surgery for patients with inoperable aortic valve stenosis disease. Aortic valve stenosis is an age-related disease caused by calcium deposits in the valve that cause it to narrow and stiffen... (Source: bizjournals.com Health Care:Hospitals headlines)
Categories: Publications

Memorial Hermann/UTHealth Implants First New Aortic Valve in Houston

Wed, 11/23/2011 - 13:00
HOUSTON, Nov. 23, 2011 (GLOBE NEWSWIRE) -- Cardiologists and cardiovascular surgeons at The University of Texas Health Science Center at Houston (UTHealth) and Memorial Hermann Heart & Vascular Institute (HVI) are the first in Houston to implant the artificial heart valve recently approved by the Food and Drug Administration (FDA), as well as a newer, smaller version that is part of a clinical trial. (Source: Medical News (via PRIMEZONE))
Categories: Publications

10 outlandish things the 'scientific' controllers have in mind for you in the near future

Wed, 11/23/2011 - 06:00
(NaturalNews) What corporate-driven "science" has in mind for the future of humanity is far different from the dreamy utopian landscape that's been portrayed by the mainstream media. To hear the corporate-run media tell it, science is always "good" for humanity. Scientific achievements are always called "advances" and not "setbacks," even though many of them have proven to be disastrous for humanity (atomic bombs, for example, or GMOs).While pure science is, indeed, a necessary component of any civilization which seeks to expand its understanding of the universe, what we see dominating the landscape today isn't pure science but corporate-driven "science" that only seeks to accelerate corporate profits, not human understanding. And with that corporate-slanted science comes a whole new era o...
Categories: Publications

Incidence and outcome of Levitronix CentriMag support as rescue therapy for early cardiac allograft failure: a United Kingdom national study [Original articles]

Wed, 11/23/2011 - 04:00
Conclusions: Primary graft failure remains an important early complication of heart transplantation. Levitronix CentriMag support led to the salvage of 32% of patients with severe allograft failure. (Source: European Journal of Cardio-Thoracic Surgery)
Categories: Publications

Implications of acute kidney injury after heart transplantation: what a surgeon should know [Original articles]

Wed, 11/23/2011 - 04:00
Conclusions: AKI is a highly prevalent and prognostically important complication. Some of the risk factors for AKI identified may be modifiable. (Source: European Journal of Cardio-Thoracic Surgery)

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Categories: Publications

Bloodstream infection in heart transplant recipients: 12-year experience at a university hospital in Taiwan [Original articles]

Wed, 11/23/2011 - 04:00
Conclusions: There was a high incidence of BSI after heart transplantation in Taiwan, especially infections caused by Enterobacter species and A. baumannii. Mortality was high in patients with infection caused by Pseudomonas, Candida, and Cryptococcus and in patients with severe sepsis. (Source: European Journal of Cardio-Thoracic Surgery)
Categories: Publications

Assessing the potential of international organ exchange -- the Swiss experience [Original articles]

Wed, 11/23/2011 - 04:00
Conclusions: International organ exchange is a very valuable and effective way to allocate a maximum of medically suitable organs to recipients on the waiting list. Organ exchange is lifesaving, especially in children, and also in patients with rare blood groups. A professional structure within the national organ procurement organisations, and a close cooperation between them on an international level, is crucial to achieve organ exchange on a high-quality level in Europe. (Source: European Journal of Cardio-Thoracic Surgery)
Categories: Publications

Adaptive growth and remodeling of transplanted hearts in children [Original articles]

Wed, 11/23/2011 - 04:00
Conclusions: This study demonstrates that the transplanted heart undergoes remodeling processes and grows adaptively, in accordance to the BSA, over a period of time. (Source: European Journal of Cardio-Thoracic Surgery)
Categories: Publications

Long-term patency of the stapled bovine pericardial conduit for replacement of the superior vena cava [Original articles]

Wed, 11/23/2011 - 04:00
Conclusions: The stapled bovine pericardial conduit is a simple, expeditious, and economic solution to SVC replacement, and offers reliable long-term patency without permanent anticoagulation. (Source: European Journal of Cardio-Thoracic Surgery)
Categories: Publications

Impact of Virtual Cross Match on Waiting Times for Heart Transplantation [ORIGINAL ARTICLES: ADULT CARDIAC]

Wed, 11/23/2011 - 04:00
Conclusions In sensitized heart transplant candidates, virtual cross match may shorten waiting time to heart transplantation without increasing subsequent occurrence of cellular rejection, antibody mediated rejection, and mortality after heart transplantation. (Source: The Annals of Thoracic Surgery)

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Categories: Publications

Excellent Outcomes With Use of Synthetic Vascular Grafts for Treatment of Mycotic Aortic Pseudoaneurysms After Heart Transplantation [ORIGINAL ARTICLES: ADULT CARDIAC]

Wed, 11/23/2011 - 04:00
Conclusions A synthetic vascular graft to replace the infected aorta is a viable aortic substitute among transplant recipients, and in the presence of a vascularized flap, can offer excellent midterm outcomes. (Source: The Annals of Thoracic Surgery)
Categories: Publications

Invited Commentary [ORIGINAL ARTICLES: ADULT CARDIAC]

Wed, 11/23/2011 - 04:00
(Source: The Annals of Thoracic Surgery)
Categories: Publications

Soluble ST2 Is a Marker for Acute Cardiac Allograft Rejection [ORIGINAL ARTICLES: ADULT CARDIAC]

Wed, 11/23/2011 - 04:00
Conclusions sST2 concentrations are modulated by the presence of acute rejection and provide complementary predictive ability to NT-proBNP for the biochemical identification of rejection. (Source: The Annals of Thoracic Surgery)
Categories: Publications

Extracorporeal Membrane Oxygenation for Advanced Refractory Shock in Acute and Chronic Cardiomyopathy [ORIGINAL ARTICLES: ADULT CARDIAC]

Wed, 11/23/2011 - 04:00
Conclusions Extracorporeal membrane oxygenation in advanced refractory AMI-CS is associated with acceptable outcomes in a well-selected population. The ECMO in patients with an acute decompensation of a chronic CM should be carefully considered, to avoid futile support. (Source: The Annals of Thoracic Surgery)
Categories: Publications

Ex vivo diffusion tensor MRI of human hearts: Relative effects of specimen decomposition

Wed, 11/23/2011 - 04:00
In this study, we describe the ability to reconstruct local fiber orientation within a unique set of human hearts using diffusion tensor MRI; relative effects of specimen decomposition were also assessed. The mean diffusivity, fractional anisotropy, and principal eigenvalues (E1, E2, and E3) were measured in hearts with varying postmortem intervals from 0 to 27 days (n = 17), and local fiber orientations were reconstructed. Mean diffusivities and principal eigenvalues nonlinearly increased as a function of postmortem interval, while fractional anisotropies nonlinearly decreased. There were good correlations between postmortem intervals and changes in diffusion properties after linear transformation of the data (R2 > 0.7). Thus, we determined that there were regional discontinuities in t...

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Categories: Publications

Polish artificial heart program

Tue, 11/22/2011 - 04:00
AbstractDespite significant advances in the development of artificial heart substitutes, anthrombogenic materials and surfaces remain to be the main challenge for implants, which can prevent thrombosis that leads to rejection. The goal of material engineering is essentially to design polymeric materials of high durability and optimal thrombogenicity in mechanical heart prosthesis, being developed recently in a frame of the polish artificial heart program. For these reasons, various surface modifications are being continuously developed for a ‘gold standard’ material, which is a polyurethane (PU) thermoplastic elastomer and they will be shortly reviewed. However, new polymeric materials can meet medical word's attention if they are able to provide similar or better characteristics in te...
Categories: Publications

Chronic cardiac allograft rejection: critical role of ED‐A+ fibronectin and implications for targeted therapy strategies

Mon, 11/21/2011 - 04:00
AbstractChronic cardiac allograft rejection is characterized by cardiac allograft vasculopathy (CAV) and cardiac interstitial fibrosis (CIF) causing severe long‐term complications after heart transplantation and determining allograft function and patients' prognosis. Until now, there are no sufficient preventive or therapeutic strategies. CAV and CIF are accompanied by changes in the extracellular matrix, including re‐expression of the fetal fibronectin splice variant known as ED‐A+ fibronectin. This molecule has been shown to be crucial for the development of myofibroblasts (MyoFb) as the main cell type in CIF and for the activation of vascular smooth muscle cells (VSMCs) as the main cell type in CAV. Relevant re‐expression and protein deposition of ED‐A+ fibronectin has been de...
Categories: Publications

A case report and review of the literature on bilateral retinal infarction following cardiopulmonary bypass for coronary artery bypass grafting

Mon, 11/21/2011 - 04:00
Postoperative visual loss is a devastating perioperative complication. The commonest aetiologies are anterior ischaemic optic neuropathy (AION), posterior ischaemic optic neuropathy (PION), and central retinal artery occlusion (CRAO). These appear to be related to certain types of operation, most commonly spinal and cardiac bypass procedures; with the rest divided between: major trauma causing excessive blood loss; head/neck and nasal or sinus surgery; major vascular procedures (aortic aneurysm repair, aorto-bifemoral bypass); general surgery; urology; gynaecology; liposuction; and liver transplantation. The non-surgical risk factors are multifactorial: advanced age, prolonged postoperative anaemia, positioning (supine v prone), alteration of venous drainage of the retina, hypertension, sm...
Categories: Publications

Establishing the Carcinogenic Risk of Immunomodulatory Drugs.

Mon, 11/21/2011 - 04:00
Authors: Weaver JL Abstract The first effective immunosuppressive drug (ISD) was azathioprine, approved in 1968. Early experience with this drug suggested that patients might have an excess risk of tumors including lymphoma and skin tumors. Comparison among various registries has shown that the cumulative risk of tumors increases over time. The risk is additionally increased by the more intense immunosuppressive regimens needed for lung or heart-lung transplants. The link between immunosuppression and tumorigenesis was further reinforced by the high concordance of tumor types between transplant and HIV patients. The role of the immune system in tumor defense includes both direct tumor surveillance and immunity against oncogenic viruses. In transplant patients, at least two-thirds o...
Categories: Publications

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