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Updated: 1 hour 41 min ago

Health Highlights: April 18, 2016

Mon, 04/18/2016 - 12:26
NFL Concussion Settlement Upheld by Appeals Court Pancreas Cell Transplants Reduce Type 1 Diabetes Patients' Risk of Complications: Study Teen Ordered to Undergo Chemotherapy Says New Mass Found in Lungs Large Health Coverage Gains for Minorities Under Affordable Care Act (Source: U.S. News - Health)
Categories: Publications

High-volume lung transplant centers have lower costs and readmissions

Thu, 04/14/2016 - 20:00
High-volume lung transplant centers have lower transplantation costs and their patients are less likely to be readmitted within 30 days of leaving the hospital following surgery, according to a new study of more than 3,000 Medicare patients who received lung transplants. (Source: ScienceDaily Headlines)

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Categories: Publications

Kamada starts Alpha-1 Antitrypsin phase 2 clinical trial to prevent lung transplant rejection

Wed, 04/06/2016 - 22:00
Kamada has started a phase 2 clinical trial with its proprietary drug Alpha-1 Antitrypsin (AAT) for preventing rejection in lung transplants, as part of a collaboration with Baxalta. (Source: Drug Development Technology)
Categories: Publications

Hope for transplant patients: Baboons survive more than two years with pig hearts

Tue, 04/05/2016 - 17:05
Researchers at the National Heart, Lung and Blood Institute in Maryland say the technique, called immunomodulation, is ready to be used in human trials for the first time (stock image pictured). (Source: the Mail online | Health)
Categories: Publications

FDA Approves Defitelio (defibrotide sodium) for Hepatic Veno-Occlusive Disease Following Hematopoietic Stem-Cell Transplantation

Wed, 03/30/2016 - 19:03
March 30, 2016 -- The U.S. Food and Drug Administration today approved Defitelio (defibrotide sodium) to treat adults and children who develop hepatic veno-occlusive disease (VOD) with additional kidney or lung abnormalities after they receive a... (Source: Drugs.com - New Drug Approvals)
Categories: Publications

Doctors at Stanford Hospital perform rare 'domino' transplant

Wed, 03/30/2016 - 18:47
Stephen FellerSTANFORD, Calif., March 30 (UPI) -- One woman received a heart-lung transplant, and her heart was then given to another woman, in an exceptionally rare surgery performed at Stanford Hospital. (Source: Health News - UPI.com)

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Categories: Publications

FDA approves first treatment for rare disease in patients who receive stem cell transplant from blood or bone marrow

Wed, 03/30/2016 - 15:10
The U.S. Food and Drug Administration today approved Defitelio (defibrotide sodium) to treat adults and children who develop hepatic veno-occlusive disease (VOD) with additional kidney or lung abnormalities after they receive a stem cell transplant from blood or bone marrow called hematopoietic stem cell transplantation (HSCT). This is the first FDA-approved therapy for treatment of severe hepatic VOD, a rare and life-threatening liver condition. (Source: Food and Drug Administration)
Categories: Publications

Bilateral lung transplantation from a donor with previous aortic valve surgery

Sun, 03/27/2016 - 21:00
In this report, we describe a case of successful bilateral lung harvest from a donor who had previously undergone aortic valve replacement. This case highlights that isolated valve surgery can be an addition to the extended donor criteria for lung retrieval and therefore increase the number of organs available for transplantation. (Source: Asian Cardiovascular and Thoracic Annals)

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Categories: Publications

Magnetic nanoparticles in cancer diagnosis and treatment: a review.

Sun, 03/27/2016 - 16:10
Authors: Fathi Karkan S, Mohammadhosseini M, Panahi Y, Milani M, Zarghami N, Akbarzadeh A, Abasi E, Hosseini A, Davaran S Abstract Diagnosis and treatment of lung cancer have been characterized with a variety of challenges. However, with the advancement in magnetic nanoparticle (MNP) technology, many challenges in the diagnosis and treatment of lung cancer are on the decline. The MNPs have led to many break-through in cancer therapy. This paper seeks to establish the role of MNPs in diagnosis and treatment of lung cancer. It proposes that the existing challenges in the diagnosis and treatment of lung cancer can be addressed through application of MNPs in the process. PMID: 27015806 [PubMed - as supplied by publisher] (Source: Artificial Cells, Nanomedicine and Biotechnology)

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Categories: Publications

Update on three-dimensional image reconstruction for preoperative simulation in thoracic surgery.

Sat, 03/26/2016 - 21:10
CONCLUSIONS: After the introduction of 3D-CT technology to the field of thoracic surgery, preoperative simulation has been developed for various thoracic procedures. In the near future, this technique will become more common in thoracic surgery, and frequent use by thoracic surgeons will be seen in worldwide daily practice. PMID: 27014477 [PubMed] (Source: Journal of Thoracic Disease)

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Categories: Publications

A study on the role of apoptotic human umbilical cord mesenchymal stem cells in bleomycin-induced acute lung injury in rat models.

Sat, 03/26/2016 - 10:11
CONCLUSIONS: Human umbilical cord mesenchymal stem cell transplantation may have a bright future in the clinical setting for the treatment of ALI/acute respiratory distress syndrome (ARDS). Apoptotic human umbilical cord mesenchymal stem cells may have more effective than normal human umbilical cord mesenchymal stem cells in the treatment of acute lung injury. PMID: 27010158 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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Categories: Publications

[Chronic hepatothorax due to right diaphragmatic rupture: an anesthetic challenge in a rare case].

Fri, 03/25/2016 - 19:50
CONCLUSIONS: Hepatothorax is a rare condition and its repair may represent an anesthetic challenge. After liver replacement in the abdominal cavity during corrective surgery under general anesthesia complications may occur, particularly associated with pulmonary re-expansion. Effective teamwork and careful planning of surgery, between the surgical and anesthetic teams, are the key to success. PMID: 27005827 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)

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Categories: Publications

Isolation of Individual Cellular Components from Lung Tissues of Patients with Lymphangioleiomyomatosis.

Thu, 03/24/2016 - 22:00
Authors: Ando K, Fujino N, Mitani K, Ota C, Okada Y, Kondo T, Mizobuchi T, Kurihara M, Suzuki K, Hoshika Y, Ebana H, Kobayashi E, Takahashi K, Kubo H, Seyama K Abstract Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease entailing cystic destruction of the lungs and progressive respiratory failure. LAM lungs are histologically characterized by the proliferation of smooth muscle-like cells (LAM cells) and an abundance of lymphatic vessels. To elucidate the pathophysiologic processes of LAM, cell type-specific analyses are required. However, no method exists for isolating the individual types of cells in LAM lesions. Therefore, we established a fluorescence-activated cell sorting (FACS)-based method for the direct isolation of LAM cells and other various cellular components f...

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Categories: Publications

HLA-DR13, DR15 are associated with short-term lung transplant outcomes

Thu, 03/24/2016 - 22:00
Lung transplantation outcomes are among the least favorable, with the majority of recipients eventually developing bronchiolitis obliterans syndrome (BOS) and subsequent graft failure. Presence of human leukocyte antigen (HLA)-DR antigens has been implicated in the pathogenesis of BOS and may play a role in these poor outcomes. (Source: Journal of Surgical Research)
Categories: Publications

What can happen after lung transplantation and the importance of the time since transplantation: radiological review of post-transplantation complications.

Tue, 03/22/2016 - 22:00
This article aims to describe and illustrate the complications that can occur after lung transplantation from the clinical and radiological viewpoints so that they can be detected as early as possible. PMID: 27017046 [PubMed - as supplied by publisher] (Source: Radiologia)
Categories: Publications

Human Alpha-1 Antitrypsin Improves Early Post-Transplant Lung Function: Pre-Clinical Studies in a Pig Lung Transplant Model

Tue, 03/22/2016 - 22:00
The translation of novel drugs in lung transplantation is challenged by different physiological conditions between small animals and humans. Large animal models provide important pre-clinical evidence and the next step that best informs clinical trials. In the present study, we used a pig lung transplant model to determine whether human alpha-1 antitrypsin (A1AT), a medication shown to prevent pulmonary ischemia-reperfusion injury in rats, could attenuate reperfusion injury after prolonged hypothermic preservation in a large animal lung transplant model. (Source: The Journal of Heart and Lung Transplantation)
Categories: Publications

Polarization of M1 tumor associated macrophage promoted by the activation of TLR3 signal pathway

Tue, 03/22/2016 - 22:00
Conclusions The Poly-ICLC can activate the TLR3 downstream signaling pathway to induce a M1 polarization of tumor associated macrophage, thereby inhibiting the tumor growth. (Source: Asian Pacific Journal of Tropical Medicine)

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Categories: Publications

Special considerations for the use of lung transplantation in pediatrics.

Tue, 03/22/2016 - 18:21
Authors: Schmid FA, Benden C Abstract Lung transplantation has become an accepted therapy in infants, children and adolescents suffering from end-stage lung diseases, an impaired quality of life as well as a reduced life expectancy. Within Europe, pediatric lung transplantation is largely performed in predominantly adult centers due to a relatively low overall case volume. Children do represent a specific and challenging cohort facing a transplant procedure, where the selection of potential candidates becomes a crucial step to maximize net survival benefit. Therefore, interdisciplinary evaluation and early listing in view of current indications and contraindications, adequate preoperative education of the child and family members, discussion of possibly required bridging procedures...

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Categories: Publications

Id: 113: the endothelial phd2/hif-2 axis regulates pulmonary artery pressure in mice

Mon, 03/21/2016 - 22:00
Conclusions Our studies identify endothelial HIF-2 as a key transcription factor in the pathogenesis of PH and suggest that HIF-2 regulates PA pressure by modulating the expression of vasoactive molecules. Our findings identify the PHD2/HIF2 axis as a potential target for PH therapies. (Source: Journal of Investigative Medicine)
Categories: Publications

Robo‐Immunity: Neuroendocrine Regulation of Inflammation in the Lung

Mon, 03/21/2016 - 22:00
New data identify a neuroendocrine pathway responsible for suppressing excessive infl ammation in the lung. (Source: American Journal of Transplantation)
Categories: Publications

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