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Updated: 1 hour 38 min ago

Better Outcomes for Patients will Provide Better Business Outcomes

Wed, 06/15/2016 - 04:47
It will not have escaped your attention that ‘patient centricity’ has become something of a catchphrase in the last couple of years: mission statements and company announcements are full of it. Cynics have yet to be convinced, but some believers in pharma are working to win them over. John McCarthy, VP Global Commercial Excellence at AstraZeneca, thinks he has the tools to make the idea something more concrete. The international team he leads has a daunting remit: to build and deliver capabilities to drive commercial success, transform the healthcare experience and improve the lives of millions of patients. Measuring the journey In short, he is leading the charge to make AstraZeneca a patient-centric organization. To know you are achieving this broad and ambitious set of aims requires ...
Categories: Publications

Treatment 'breakthrough' in man with advanced skin cancer

Tue, 05/31/2016 - 12:30
Conclusion This is described as the first case study in humans to have successfully combined these immune treatments. The results demonstrate that long-term cancer remission was achieved even after the cancer had previously progressed quickly when the person had been given IL-21, CTL and anti-CTLA4 separately. These seem to be extremely encouraging findings for metastatic melanoma, a cancer with notoriously poor prognosis. However, before the findings raise too much hope, it must be emphasised that this case report focuses on just one man. The researchers note he is one of 10 people entered into the trial of this combination treatment, and only one other person received complete remission as well. This means this treatment combination may not offer the hope of a complete cure for a...

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Categories: Publications

How Getting a Puppy Helped My Terminally Ill Teen

Mon, 05/30/2016 - 11:54
The puppy was 10 weeks old and a little over a pound the day we brought him home. He was a fancy mutt, a combination miniature poodle and Yorkshire terrier (yorkie-poo) that will likely grow no larger than five or six pounds. My 14-year-old daughter was in Manhattan getting radiation for tumors in her lungs the day I picked him up - he was a surprise that would be waiting for her that night. I'd originally told her we would get a dog when radiation treatments were over -- something for her to look forward to after three weeks of daily trips to the hospital (a six-hour round trip from our home in the Hudson Valley). I kept my younger daughter home from school the day we got him, mostly because I was terrified of being alone with a dog, even one so small. I've been a cat person all my life...
Categories: Publications

Childhood abuse is associated with worse survival following lung transplantation - Kennedy CC, Zubair A, Clark MM, Jowsey-Gregoire S.

Fri, 05/27/2016 - 13:26
CONTEXT: Psychosocial factors can impact lung transplant outcomes. However, it is currently unknown whether abuse survivorship influences lung transplant survival. OBJECTIVE: To characterize the abuse history of adult lung transplant patients and d... (Source: SafetyLit)
Categories: Publications

TransMedics closes $51.2m round to support its Organ Care System

Thu, 05/26/2016 - 15:45
TransMedics said today it closed a $51.2 million round of equity financing to support its Organ Care System organ preservation device. The company’s flagship Organ Care System is designed to perfuse donor organs with warm, oxygenated blood and monitor its status until transplantation. “We are thankful and excited to be supported by a world-class syndicate of new and existing life science investors. This financing strongly positions TransMedics to capitalize on the significant market opportunity in front of us,” CEO Dr. Waleed Hassanein said in a press release. The round was co-led by the Fayerweather Fund and Pharmstandard International S.A., represented by InBio Ventures, Ervington Investments and BioStar ventures, Transmedics reported. Existing investors Abrams C...
Categories: Publications

UPMC researchers shine light on common heart complication after lung transplantation

Thu, 05/26/2016 - 03:00
(University of Pittsburgh Schools of the Health Sciences) Cardiac arrhythmia is a common complication following lung transplantation, and one that has a significant negative impact on long-term patient survival. (Source: EurekAlert! - Medicine and Health)
Categories: Publications

FDA Approves Opdivo for Hard-to-Treat Hodgkin Lymphoma

Thu, 05/19/2016 - 04:20
By Hope Cristol Patients with hard-to-treat Hodgkin lymphoma now have a new treatment option. The U.S. Food and Drug Administration granted accelerated approval to Opdivo (nivolumab) for classic Hodgkin lymphoma that has returned or progressed after a specific type of stem cell transplant and post-transplant medicine. Hodgkin lymphoma is a cancer of the lymph system, which is part of the immune system. There are two main types of this disease, but “classic” Hodgkin lymphoma accounts for about 95% of all cases in developed countries. The American Cancer Society estimates about 8,500 new cases of Hodgkin lymphoma will be diagnosed in 2016, with a 5-year survival rate ranging from 90% for stage I to 65% for stage IV. When Hodgkin lymphoma comes back after treatment (relapsed ...

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Categories: Publications

U.S. trial test machine that ‘reconditions’ lungs outside body

Wed, 05/18/2016 - 15:09
(Reuters) – A machine that ‘reconditions’ a donor’s lungs outside the body before being transplanted into a recipient is undergoing tests in the United States in the hope that it can radically improve survival rates for people with chronic respiratory diseases. The XPS, manufactured by Swedish company XVIVO Perfusion , is in clinical trials at 16 U.S. medical centers. Known as “the box,” it ventilates the lungs after removal from the donor and infuses them with a fluid mix of drugs and steroids, effectively drying them out and getting them in better shape for use in a transplant operation. The technology, which has not been used widely before, aims to increase the donor pool by reconditioning marginal lungs not suitable for transplant. “It allows t...
Categories: Publications

Penis transplant: welcome to the frontier of a fascinating science | Celine Gounder

Tue, 05/17/2016 - 13:43
Transplant medicine has overcome problems of infection, rejection and surgical complexity. Now we just need more people to become donorsThe first penile transplant in the US was performed on cancer survivor Thomas Manning at Harvard’s Massachusetts General Hospital last week. This paves the way for the treatment of other cancer patients, wounded veterans, burn victims and all those who’ve suffered genital trauma or needed radical surgery to save their lives. Transplanting a penis is technically much simpler than transplanting a lung or liver, so why did it take this long?Transplant medicine is much older than many realize. Over 3,000 years ago, the ancient Indian physician Sushruta used skin transplants – more commonly today called grafts – to reconstruct noses amputated as punishm...
Categories: Publications

Antibody-Mediated Rejection in Lung TransplantationAntibody-Mediated Rejection in Lung Transplantation

Wed, 05/11/2016 - 07:17
Antibody-mediated rejection may negatively impact lung transplant prognosis, according to a new study. American Journal of Transplantation (Source: Medscape Today Headlines)
Categories: Publications

Researchers find bioreactor supports whole lung regeneration

Wed, 05/04/2016 - 16:54
Stephen FellerWASHINGTON, May 4 (UPI) -- Researchers at Yale University devised a mechanical system that can support the growth of whole lungs from patient cells to use in transplants. (Source: Health News - UPI.com)
Categories: Publications

HeartWare dives on big Q1 sales, earnings misses

Wed, 05/04/2016 - 12:37
Shares prices for HeartWare International (NSDQ:HTWR) plunged this morning after the implantable heart pump maker posted 1st-quarter earnings that badly missed expectations on Wall Street. Framingham, Mass.-based HeartWare reported that losses widened 20.1% to -$17.5 million, or -$1 per share, on a -21.3% revenue slide to $55.1 million. Adjusted to exclude 1-time items, losses per share were -95¢, -16¢ off the forecast on The Street, where analysts were looking for sales of $59.9 million. “In the 1st quarter, our international revenue performance was impacted by competitive dynamics in Germany, as well as lower implant volumes in certain other international markets,” president & CEO Doug Godshall said in prepared remarks. “In the U.S., the bridge-to-transplant s...

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Categories: Publications

Double lung transplant recipient gives back to group that fought on his behalf

Tue, 05/03/2016 - 15:12
A man who successfully received a double lung transplant three years ago is giving back to the Lung Association of Nova Scotia. (Source: CBC | Health)
Categories: Publications

New research from Yale and MIT describes bioreactor to support whole lung regeneration

Tue, 05/03/2016 - 03:00
(Mary Ann Liebert, Inc./Genetic Engineering News) An innovative mechanical system that mimics the ventilation and blood flow in the chest cavity, housed in a specialized, sterile bioreactor, can support the growth of engineered whole lungs at human scale. Researchers designed this biomimetic environment to advance toward clinical application of whole lung regeneration for transplant using a patient's own cells, as described in BioResearch Open Access. (Source: EurekAlert! - Medicine and Health)
Categories: Publications

Older Lung Donors Raise Mortality Risk Only SlightlyOlder Lung Donors Raise Mortality Risk Only Slightly

Mon, 05/02/2016 - 15:42
Pushing the maximum recommended donor age for lung transplants from 55 to 64 years greatly expands the donor pool, with only a slight increase in recipient mortality. However, more research is needed. Medscape Medical News (Source: Medscape Transplantation Headlines)
Categories: Publications

Teacher Runs 5K Months After Undergoing Double Lung Transplant

Sat, 04/30/2016 - 23:50
BOSTON (CBS) — For 32-year-old Eamonn Kelly, crossing the finish line during a 5K race this weekend is more than just a dream come true; it’s really a new start at life. “I’m going to set my goal and do it,” he told WBZ. Kelly was born with cystic fibrosis, a genetic disease that affects the lungs. The older he got, the more his life began to deteriorate, he said. “Before the transplant, I was on oxygen 24-7,” Kelly says. “I had to carry a tank with me and it made life difficult for me.” Refusing to accept life this way, Kelly underwent a double lung transplant at Massachusetts General Hospital exactly six months ago today. #Brighton teacher Eamonn Kelly runs 1st ever 5k@BostonCollege 6 months after undergoing double lung transplant. #wb...
Categories: Publications

Cancer Screening Tests All Women Should Know About

Fri, 04/29/2016 - 11:45
By Stacy Simon Along with giving Mother's Day gifts and sending greetings this year, encourage the moms in your life to get up to date on cancer screening tests. Screening tests look for cancer before a person has any signs or symptoms. Regular screenings can catch some cancers early, when they’re small, have not spread, and are easier to treat. With cervical and colon cancers, these tests can even prevent cancer from developing in the first place. Sweeten the deal by offering to help your mom schedule her screening, drive her to and from appointments, and keep her company in the waiting room. These are the American Cancer Society’s screening recommendations:Breast cancer Women should be able to start the screening as early as age 40, if they want to. It’s a good idea t...

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Categories: Publications

Should Patients in Their 70s Get Lung Transplants?Should Patients in Their 70s Get Lung Transplants?

Thu, 04/28/2016 - 16:23
As the age of lung transplant patients increases, the age of recipients and the stewardship of organs have become controversial. Experts debated these issues at a heart and lung transplant meeting. Medscape Medical News (Source: Medscape Transplantation Headlines)
Categories: Publications

Left Ventricular Assist Results Lead Transplant MeetingLeft Ventricular Assist Results Lead Transplant Meeting

Wed, 04/20/2016 - 13:51
First-year performance results for the small implantable left ventricular assist device will be presented at the International Society for Heart and Lung Transplantation Scientific Sessions. Medscape Medical News (Source: Medscape Medical News Headlines)
Categories: Publications

International Society for Heart and Lung Transplantation (ISHLT) 2016 Scientific SessionsInternational Society for Heart and Lung Transplantation (ISHLT) 2016 Scientific Sessions

Mon, 04/18/2016 - 20:30
Read clinically focused news coverage of key developments from ISHLT 2016. Medscape Transplantation (Source: Medscape Today Headlines)
Categories: Publications

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