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Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients

Mon, 09/19/2011 - 03:00
Conclusion: Younger age and CYP3A5 expressor genotype were independently associated with higher dosing requirements and lower tacrolimus concentration/dose ratios. (Source: The Journal of Heart and Lung Transplantation)
Categories: Publications

Role of morphologic parameters on endomyocardial biopsy to detect sub-clinical antibody-mediated rejection in heart transplantation

Mon, 09/19/2011 - 03:00
Conclusions: Our results showed that histologic parameters did not always detect signs of early sub-clinical or latent stages of AMR. Combining the parameters of endothelial swelling and intracapillary mononuclear cells did not significantly improve the sensitivity or specificity. Screening recommendations should, therefore, be modified to include more sensitive tests such as C4d staining in the routine protocol to improve patient risk stratification. (Source: The Journal of Heart and Lung Transplantation)
Categories: Publications

Two years and 4 months: A long-term bridge to transplantation with a total artificial heart

Mon, 09/19/2011 - 03:00
We report our experience with a 38-year-old man with refractory end-stage biventricular heart failure due to an idiopathic dilative cardiomyopathy, who received a SynCardia temporary total artificial heart (SynCardia Systems, Inc., Tucson, AZ) as treatment. This procedure performed at our institution is the longest term bridge to heart transplantation (HTx) so far. (Source: The Journal of Heart and Lung Transplantation)
Categories: Publications

Combination of everolimus with calcineurin inhibitor medication resulted in post-transplant haemolytic uraemic syndrome in lung transplant recipients--a case series

Fri, 09/16/2011 - 03:00
Conclusions. Our data should raise the awareness of post-transplant HUS in lung transplant recipients. Post-transplant HUS is a rare disease, but it is a serious cause of acute renal failure in lung transplant recipients treated with a combination of everolimus and calcineurin inhibitors. (Source: Nephrology Dialysis Transplantation)

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Categories: Publications

Multiple extramedullary relapses without bone marrow involvement after second allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia

Fri, 09/16/2011 - 03:00
We report a case of diffuse EMR of AML without BM involvement after a second allogeneic HSCT. (Source: Pediatric Transplantation)
Categories: Publications

Autoantibody formation in human and rat studies of chronic rejection and primary graft dysfunction.

Fri, 09/16/2011 - 03:00
Authors: Wilkes DS Abstract Lung transplantation is considered a definitive treatment for many lung diseases. However, rejection and other pathologic entities are major causes of morbidity and mortality for lung transplant recipients. Primary graft dysfunction (PGD) and obliterative bronchiolitis (OB) are the leading causes of early and late mortality, respectively. While the immune basis of PGD has not been clearly defined, evidence is emerging about roles for autoantibodies in this process. Similarly, the pathogenesis of OB has been linked recently to autoimmunity. This review will highlight the current understanding of autoantibodies in PGD and OB post lung transplantation. PMID: 21925897 [PubMed - as supplied by publisher] (Source: Seminars in Immunology)
Categories: Publications

Estrogen treatment may help reverse severe pulmonary hypertension

Thu, 09/15/2011 - 15:35
UCLA researchers have found that the hormone estrogen may help reverse advanced pulmonary hypertension, a rare and serious condition that affects 2 million to 3 million individuals in the U.S., mostly women, and can lead to heart failure.   The condition causes a progressive increase in blood pressure in the main pulmonary artery, which originates in the heart's right ventricle and delivers blood to the lungs. The rise in pressure impairs heart function by enlarging the right ventricle, potentially leading to heart failure.   Published in the Sept. 15 issue of the American Journal of Respiratory and Critical Care Medicine, the preclinical study shows that in rats, estrogen treatment can reverse the progression of pulmonary hypertension to heart failure and can restore lung a...
Categories: Publications

The intensity of bronchiolar epithelial cell injury caused by an alloimmune response is ameliorated by transbronchial human interleukin-10 gene transfer in a rat model of lung transplantation

Thu, 09/15/2011 - 14:53
Abstract  The aim of the present study was to determine whether the intensity of bronchiolar epithelial cell injury is ameliorated by transbronchial human IL-10 (hIL-10) gene transfer in a rat model of lung allograft rejection. The left lung was extracted from a donor Brown Norway rat and transbronchially instilled with encoding hIL-10 (IL-10 group) or β-galactosidase (control group). The lung graft was then transplanted into a Lewis rat and harvested on day 6 after transplantation. The allografts were histologically examined and all bronchioles in the slides were assigned one of three grades according to the intensity of epithelial cell loss. The distribution of the grades was significantly different between the two groups, and the epithelial cell injury was significantly ...
Categories: Publications

Agave From Root Cuttings

Sun, 08/14/2011 - 11:47
Last February, we had a very unusual hard freeze. It killed a lot of plants. The prior year, I had gotten an agave from a local nursery. It was a nice specimen, about 12 inches wide; it cost $25. In the freeze, it died. So I removed all the dead matter above ground. In the springtime, I watered it sparingly. After a couple of months, there was no visible growth. One weekend, I went and bought a plant to replace it. The new plant is a Dasylirion wheeleri, aka sotol, or desert spoon. These things grow in the mountains, where it actually snows sometimes. Ought to be able to tolerate a freeze or two. When I dug a hole for the sotol, I found a lot of thick, moist, viable-looking root from the agave. Somewhere, sometime, I had read about propagation from root cuttings. So I used some cactus pott...
Categories: Publications

Revised Article-Lung Transplant

Tue, 05/24/2011 - 23:00
A lung transplant is surgery to remove a person's diseased lung and replace it with a healthy lung from a deceased donor. (Source: National Heart, Lung, and Blood Institute Health Topics)
Categories: Publications

Revised Article-Total Artificial Heart

Tue, 06/22/2010 - 23:00
A total artificial heart (TAH) is a device that replaces the two lower chambers of the heart. (Source: National Heart, Lung, and Blood Institute Health Topics)
Categories: Publications

Novartis kidney cancer drug clears key hurdle

Thu, 02/28/2008 - 15:43
Everolimus (RAD001) significantly extends progression-free survival in advanced kidney cancer patients after failure of other targeted therapy  Outstanding interim results cause independent data monitoring committee to immediately share findings; patients on placebo to be offered everolimus  Everolimus (RAD001) tablet, taken once daily, demonstrated highly effective anti-tumor activity through continuous targeted inhibition of mTOR  Results of RECORD-1 trial address unmet medical need in renal cell cancer with worldwide regulatory filings planned for second half of 2008  Complete results to be submitted as late-breaking abstract for presentation at the American Society of Clinical Oncology meeting  Basel, February 28, 2008 — An independent data ...

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Categories: Publications

Revised Article-Heart Transplant

Wed, 12/31/1969 - 23:00
A heart transplant is surgery to remove a diseased heart and replace it with a healthy heart from a deceased donor. (Source: National Heart, Lung, and Blood Institute Health Topics)
Categories: Publications

Revised Article-Blood and Marrow Stem Cell Transplant

Wed, 12/31/1969 - 23:00
A blood and marrow stem cell transplant is a procedure that replaces a person's faulty stem cells with healthy ones. (Source: National Heart, Lung, and Blood Institute Health Topics)
Categories: Publications

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