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Elevation of Antidonor Immunoglobulin M Levels Precedes Acute Lung Transplant Rejection [ORIGINAL ARTICLES: GENERAL THORACIC]

Wed, 09/28/2011 - 03:00
Conclusions Significant immunoreactivity of IgM, but not IgG, preceded the clinical onset of acute rejection. Antidonor IgM monitoring can contribute to the early detection of steroid-responsive acute rejection. (Source: The Annals of Thoracic Surgery)

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Categories: Publications

Transplantation of High Panel-Reactive Antibody Left Ventricular Assist Device Patients Without Crossmatch Using On-Bypass Pheresis and Alemtuzumab [ORIGINAL ARTICLES: ADULT CARDIAC]

Wed, 09/28/2011 - 03:00
Conclusions Heart transplantation with plasmapheresis and alemtuzumab in HS LVAD patients, most with a positive crossmatch, does not compromise midterm survival. The expected higher rates of rejection, especially beyond the first postoperative year, demand adjustments in surveillance strategies and immunosuppressive management. (Source: The Annals of Thoracic Surgery)
Categories: Publications

More data reignite debate on ARB-lung cancer risk

Tue, 09/27/2011 - 15:15
A new study, this time in kidney-transplant recipients, has found that those who took ACE inhibitors or angiotensin-receptor blockers had an increased risk of respiratory tumors if they also had a history of smoking. Some dismiss the findings, but others say they warrant further investigation. (Source: theHeart.org)
Categories: Publications

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation [Medical Sciences]

Tue, 09/27/2011 - 03:00
Primary tumors facilitate metastasis by directing bone marrow-derived cells (BMDCs) to colonize the lungs before the arrival of cancer cells. Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, and LOX-like 4, which catalyze collagen cross-linking in the lungs before BMDC recruitment. Only a subset of LOX family members was expressed in any individual breast cancer, but HIF-1 was required for expression in each case. Knockdown of HIF-1 or hypoxia-induced LOX family members reduced collagen cross-linking, CD11b+ BMDC recruitment, and metastasis formation in the lungs of mice after orthotopic transplantation of human ...
Categories: Publications

Accurate identification of geological samples using artificial neural network processing of laser-induced breakdown spectroscopy data

Mon, 09/26/2011 - 22:12
J. Anal. At. Spectrom., 2011, Advance ArticleDOI: 10.1039/C1JA10093A, PaperSiu-Lung Lui, Alexander KoujelevAn improved artificial neural network algorithm is developed for the identification of rock samples using their LIBS spectra.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Anal. At. Spectrom. latest articles)
Categories: Publications

A new alternative for bony chest wall reconstruction using biomaterial artificial rib and pleura: animal experiment and clinical application [Original articles]

Mon, 09/26/2011 - 03:00
Conclusions: Porcine-derived ribs and pleura can be employed safely to create an artificial chest wall to repair bony chest defects. The clinical results corresponded well with those of animal experiments, and thus confirmed the safety and feasibility of this new alternative of chest wall reconstruction. However, a long-term study in a large number is needed due to the small number of animals in this study. (Source: European Journal of Cardio-Thoracic Surgery)

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Categories: Publications

Cold-induced injury to lung epithelial cells can be inhibited by iron chelators -- implications for lung preservation [Original articles]

Mon, 09/26/2011 - 03:00
Conclusion: Hypothermic storage of lung cells leads to iron-dependent oxidative cell injury. These results suggest that the addition of iron chelators to existing or novel preservation solutions might decrease lung preservation injury, and this should now be tested in experimental lung transplantation. (Source: European Journal of Cardio-Thoracic Surgery)
Categories: Publications

Early effects of the ex vivo evaluation system on graft function after swine lung transplantation [Original articles]

Mon, 09/26/2011 - 03:00
Conclusions: Negative effects of the ex vivo system were limited and seen only in the immediate post-transplant period. Therefore, in DCD swine lung transplantation, the ex vivo system appears to be safe. (Source: European Journal of Cardio-Thoracic Surgery)
Categories: Publications

18F-FDG PET/CT for diagnosing infectious complications in patients with severe neutropenia after intensive chemotherapy for haematological malignancy or stem cell transplantation

Sat, 09/24/2011 - 04:46
Conclusion   18F-FDG PET/CT scanning during chemotherapy-induced febrile neutropenia and increased CRP is able to detect localized foci of infection and inflammation despite the absence of circulating neutrophils. Besides its potential role in detecting CVC-related infection during febrile neutropenia, the high negative predictive value of 18F-FDG PET/CT is important for avoiding unnecessary diagnostic tests and therapy. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00259-011-1939-1Authors Fidel J. Vos, Department of Internal Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The NetherlandsJ. Peter Donnelly, Department of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsW...
Categories: Publications

The Significance of Elevated Tumor Markers among Patients with Idiopathic Pulmonary Fibrosis Before and After Lung Transplantation.

Thu, 09/22/2011 - 03:00
CONCLUSIONS:CA 15-3 levels may predict disease severity in IPF. Levels decreased in patients with IPF but not with COPD following LTX and were not associated with malignancy. This novel and preliminary observation suggests that mucin has a role in the pathogenesis of IPF and possibly is a marker for disease activity. PMID: 21940773 [PubMed - as supplied by publisher] (Source: Chest)
Categories: Publications

A current viewpoint of lymphangioleiomyomatosis supporting immunotherapeutic treatment options.

Thu, 09/22/2011 - 03:00
A CURRENT VIEWPOINT OF LYMPHANGIOLEIOMYOMATOSIS SUPPORTING IMMUNOTHERAPEUTIC TREATMENT OPTIONS. Am J Respir Cell Mol Biol. 2011 Sep 22; Authors: Dilling DF, Gilbert ER, Picken MM, Eby J, Love RB, Le Poole IC Abstract Lymphangioleiomyomatosis (LAM) leads to hyperproliferation of abnormal smooth muscle cells in the lungs, associated with diffuse pulmonary parenchymal cyst formation and progressive dyspnea on exertion. The disease targets women of child-bearing age. Complications include pneumothoraces and chylous pleural effusions. Ten-year survival is estimated at 70% and currently, lung transplantation remains the only validated treatment. It has been observed that LAM cells express markers associated with melanocytic differentiation, including gp100 and MART1. Other melano...

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Categories: Publications

A shift in the Collagen V antigenic epitope leads to T‐helper phenotype switch and immune response to self‐antigen leading to chronic lung allograft rejection

Wed, 09/21/2011 - 14:37
In this study, we defined the role for the shift in immunodominant epitopes of Col‐V in inducing T helper phenotype switch leading to immunity to Col‐V and BOS. Sera and lavage from BOS+ LTx recipients with antibodies (Abs) to Col‐V were analyzed. Two years prior to BOS, patients developed Abs to both Col‐V,α1(V) and α2(V) chains. However, at clinical diagnosis of BOS, Abs became restricted to α1(V). Further, lung biopsy from BOS(+) patients bound to Abs to α1(V) indicating that these epitopes are exposed. Fourteen Col‐V peptides (pep1‐14, pep1 to 4 specific to α1(V), pep5‐8 to α1,2(V) and pep9‐14 to α2(V)) which bind to HLA‐DR4 and DR7, demonstrated that prior to BOS, pep 6,7,9,11 and 14 were immunodominant and induced IL‐10. However, at BOS, the response switch...
Categories: Publications

Airway Function Improves Following Anti-Reflux Surgery Both Before And After Lung Transplant

Wed, 09/21/2011 - 06:00
Surgery to correct gastroesophageal reflux disease, or GERD, can preserve lung function in patients with end-stage pulmonary disease both before and after transplantation, according to a new study from the University of Pittsburgh School of Medicine. The findings, published in the Archives of Surgery, suggest that esophageal testing should be performed more frequently among these patients to determine if anti-reflux surgery is needed... (Source: Health News from Medical News Today)
Categories: Publications

Omental flap transposition with intra-abdominal relocation for LVAD pump-pocket infection

Wed, 09/21/2011 - 03:00
We report salvage of a left ventricular assist device (LVAD) with a complex pump-pocket infection by intra-abdominal relocation and omental transposition. A 59-year-old diabetic male with valvular cardiomyopathy underwent HeartMate II (Thoratec Corporation, Pleasanton, CA) implantation as a bridge to transplantation. Two months post-operatively he developed staphylococcal septicemia with abscess collection involving the pump pocket. There was no evidence of endocarditis or device vegetations by transesophageal echocardiography. (Source: The Journal of Heart and Lung Transplantation)
Categories: Publications

Ambulatory veno-venous extracorporeal membrane oxygenation: Innovation and pitfalls

Tue, 09/20/2011 - 15:41
Conclusions: Improvements in the durability of membrane blood oxygenators and pumps have prompted renewed consideration of extracorporeal membrane oxygenation in patients with severe lung disease. This report describes an attempt to augment extracorporeal membrane oxygenation with the goal of ambulation by minimizing mechanical ventilatory support and using aggressive in-and-out-of-bed rehabilitation. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Categories: Publications

Anti-reflux surgery helps airway function both before and after lung transplant

Tue, 09/20/2011 - 11:22
(Source: Cystic Fibrosis Worldwide)

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Categories: Publications

How does successful bridging with ventricular assist device affect cardiac transplantation outcome? [Best evidence topic - Assisted circulation]

Tue, 09/20/2011 - 03:00
A best evidence topic in cardiac surgery was written according to a structured protocol. The issue was to determine the impact of bridge-to-transplant ventricular assist device support on survival after cardiac transplantation. Altogether 428 papers were found using the reported search, of which 12 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. The treatment options for patients with advanced heart failure or those with deteriorating end-organ function on maximal medical therapy are limited to intravenous inotropes and mechanical assistance with intra-aortic balloon pump (IABP) or ventricular assist device (VAD). Studies expl...
Categories: Publications

Successful treatment of parapneumonic empyema after H1N1 infection in a heart transplant recipient [Case report - Thoracic non-oncologic]

Tue, 09/20/2011 - 03:00
Pandemic influenza A H1N1 virus is likely to cause severe disease in patients who have received solid organs transplants. In these patients pneumonia is the most frequent clinical feature. Parapneumonic empyema (PPE) may represent the evolution of secondary bacterial respiratory infections. To our knowledge this is the first reported case of PPE during H1N1 influenza A in an adult heart transplanted patient. The patient was treated successfully with surgical empyemectomy and lung decortication, broad-spectrum antibiotics and oseltamivir. Eradication of influenza was obtained in the fifth postoperative day. (Source: Interactive CardioVascular and Thoracic Surgery)
Categories: Publications

Respiratory failure in patients undergoing allogeneic hematopoietic SCT—a randomized trial on early non-invasive ventilation based on standard care hematology wards

Mon, 09/19/2011 - 03:00
Respiratory failure in patients undergoing allogeneic hematopoietic SCT—a randomized trial on early non-invasive ventilation based on standard care hematology wards Bone Marrow Transplantation advance online publication, September 19, 2011. doi:10.1038/bmt.2011.160 Authors: M Wermke, S Schiemanck, G Höffken, G Ehninger, M Bornhäuser & T Illmer (Source: Bone Marrow Transplantation)
Categories: Publications

Antireflux Surgery Preserves Lung Function in Patients With Gastroesophageal Reflux Disease and End-stage Lung Disease Before and After Lung Transplantation [Paper]

Mon, 09/19/2011 - 03:00
Conclusions  There should be a low threshold for performing objective esophageal testing including esophageal impedance because GERD may be occult and ARS may improve or prolong allograft and native lung function. (Source: Archives of Surgery)
Categories: Publications

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