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The role of nonautologous and autologous adipose-derived mesenchymal stem cell in acute pyelonephritis.

Sat, 12/09/2017 - 13:45
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The role of nonautologous and autologous adipose-derived mesenchymal stem cell in acute pyelonephritis.

Cell Tissue Bank. 2017 Dec 07;:

Authors: Sabetkish S, Sabetkish N, Talebi MA, Halimi S, Kajbafzadeh AM

Abstract
We compared the therapeutic effects of autologous and nonautologous adipose-derived mesenchymal stem cell (ADMSC), in ameliorating the renal function in a rabbit model of acute pyelonephritis. The difference of perirenal and neck subcutaneous ADMSCs were also evaluated. Twenty female rabbits were apportioned to 5 groups. In group I (n = 4), the rabbits were injected direct inoculation of Escherichia coli (E. coli) into the right kidney. In group II (n = 4), autologous ADMSCs obtained from nape adipose tissue were injected into the subcapsular space 1 week after E. coli injection, while nonautologous ADMSCs of the same origin (from male rabbits) were applied in group III (n = 4). In group IV (n = 4), autologous perirenal ADMSCs were applied with the same method, while perirenal nonautologous ADMSCs from male rabbits were used in group V (n = 4). Technetium-99m-DMSA renal scan was performed 1, 2 and 4 months post-injection in all groups. Kidneys were excised for the evaluation of histopathological changes in the same time points. PCR examination for detection of Y-chromosome (in group III and V) and fluorescent evaluation (in group II and IV) were also performed to determine the fate of injected cells. Injection of autologous ADMSCs resulted in more satisfactory outcomes in reduction of interstitial fibrosis, tubular, and glomerular atrophy as compared to nonautologous groups. However, histopathological ameliorations were significantly better in group IV in which autologous perirenal ADMSC was applied. Remarkably, two months after the injection, Technetium-99m-DMSA renal scan showed that right kidney reached to near normal cortical function (48 and 45%) in group IV and V, respectively as compared to groups II (41%) and III (37%). Autologous ADMSCs may have better results in cell therapy as compared to nonautologous cells. However, more satisfactory outcomes may be obtained when the cell source is selected from the surrounding adipose tissue.

PMID: 29218427 [PubMed - as supplied by publisher]

Age-associated alteration in Th17 cell response is related to endothelial cell senescence and atherosclerotic cerebral infarction.

Sat, 12/09/2017 - 13:45
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Age-associated alteration in Th17 cell response is related to endothelial cell senescence and atherosclerotic cerebral infarction.

Am J Transl Res. 2017;9(11):5160-5168

Authors: Li Q, Ding S, Wang YM, Xu X, Shen Z, Fu R, Liu M, Hu C, Zhang C, Cao Q, Wang Y

Abstract
T-helper 17 (Th17) cells produce Interleukin-17 (IL-17) that plays an important role in host-defense. However, little is known whether aging affects the functions of human Th17 cells. In this study, we examine age-associated alteration in Th17-cell response; correlation between Th17-cells and endothelial cell senescence; and the occurrence of acute cerebral infarction (ACI). First, we examined Th17-frequency, phenotyping, key transcription factors, and relevant cytokines in healthy elderly, middle-aged and young-people along with elderly-patients with ACI. We detected levels of endothelial cell senescence markers in mRNA and inflammatory biomarker in serum among the groups. Correlations of Th17 frequency to levels of cytokines and endothelial cell senescence biomarkers have been analyzed. Finally, effects of IL-17 on endothelial cell senescence were explored in vitro. Our study demonstrated that healthy elderly-people have an increased Th17 frequency, RORγt expression and Th17 related cytokines (IL-17, IL-6) levels in peripheral blood compared to healthy middle-aged and young-people. Furthermore, elderly-ACI patients also have an increased Th17 expression as compared to healthy elderly-people. There was no significant difference in levels of memory Th17 frequency among the 4 groups, indicating that IL-17 is mainly produced by memory CD4+ T cells. There were no significant correlations between Th17 frequencies, levels of cytokines, inflammatory biomarkers in serum and endothelial cell senescence biomarkers in mRNA. Cell experiments about human umbilical vein endothelial cells (HUVECs) co-culture with IL-17 demonstrated that IL-17 promotes endothelial cell senescence which is closely related to ACI occurrence. Our results suggested that aging and ACI occurrence strengthen Th17-cell response. Th17/IL-17 may promote endothelial cell senescence, subsequently contributing to ACI occurrence in humans.

PMID: 29218113 [PubMed]

Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.

Sat, 12/09/2017 - 13:45
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Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.

Front Immunol. 2017;8:1615

Authors: Schroder PM, Ezekian B, Ford M, Knechtle SJ, Kwun J

PMID: 29218048 [PubMed]

Nontubercular Mycobacterial Infection in a Renal Allograft Recipient.

Sat, 12/09/2017 - 13:45
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Nontubercular Mycobacterial Infection in a Renal Allograft Recipient.

Indian J Nephrol. 2017 Nov-Dec;27(6):478-481

Authors: Anandh U, Jayanna K

Abstract
A 71-year-old male, a renal allograft recipient, presented to us with a history of fever and right palm swelling. He had a history of fever 7 years back when he was treated with antitubercular treatment (ATT). Three years back, he was diagnosed to have gout and he was started on allopurinol. He developed severe bone marrow toxicity and allopurinol was changed to febuxostat. On admission, routine investigations did not reveal any focus of infection. The fluid aspirate from the palm revealed acid-fast bacilli (AFB). He was started on ATT; however, he did not show significant improvement. Two months later, he developed multiple subcutaneous lesions, and the pus again came positive for AFB. Due to lack of improvement, the aspirate was sent for molecular diagnostic identification. The mycobacteria was identified as Mycobacterium haemophilum. His treatment was changed to rifampicin, clarithromycin, and ciprofloxacin. As he showed slow improvement, his immunosuppression was tapered slowly. At 7 months of therapy, he is clinically better and his lesions are healing. His renal functions stayed stable despite tapering of cyclosporine in a patient who is on rifampicin. This case, the first report of M. haemophilum infection in a kidney transplant recipient in India, illustrates the difficulty in diagnosing nontubercular mycobacterial infection in transplant recipients. It also emphasizes the dilemma in tapering immunosuppressive drugs in disseminated nontubercular mycobacterial infections where there are considerable interactions between ATT and immunosuppressives.

PMID: 29217890 [PubMed]

Renal Complications of Hematopoietic Stem Cell Transplantation: Report of a Case and Review of the Literature.

Sat, 12/09/2017 - 13:45
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Renal Complications of Hematopoietic Stem Cell Transplantation: Report of a Case and Review of the Literature.

Indian J Nephrol. 2017 Nov-Dec;27(6):468-471

Authors: Liquete E, Williamson SR, Janakiraman N, Venkat KK

Abstract
We report the development of minimal change disease superimposed on preexisting chronic kidney disease secondary to chronic calcineurin inhibitor nephrotoxicity in a hematopoietic stem cell transplantation (HSCT) recipient and review the renal complications of HSCT.

PMID: 29217887 [PubMed]

Proteomic Analysis of Perfusate from Machine Cold Perfusion of Transplant Kidneys: Insights Into Protection from Injury.

Sat, 12/09/2017 - 13:45
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Proteomic Analysis of Perfusate from Machine Cold Perfusion of Transplant Kidneys: Insights Into Protection from Injury.

Ann Transplant. 2017 Dec 08;22:730-739

Authors: Moser MAJ, Sawicka K, Arcand S, O'Brien P, Luke P, Beck G, Sawicka J, Cohen A, Sawicki G

Abstract
BACKGROUND Machine cold perfusion is beneficial to the preservation of kidneys for transplantation. At the end of preservation, the perfusion solution contains many proteins. Using a proteomics approach, we searched for useful biomarkers and potential therapeutic targets in the perfusate. Our program is unique in that all transplant kidneys (even living donor kidneys, LKD) are placed on machine cold perfusion prior to transplantation. MATERIAL AND METHODS Perfusates from donation after neurological and circulatory determination of death (DNDD and DCDD respectively) and LKD were collected (n=41) and analyzed for LDH, neutrophil gelatinase-associated lipocalin (NGAL), and matrix metalloproteinase-2 (MMP-2) as markers of injury. Perfusate from each kidney was subjected to 2-dimensional gel electrophoresis, then analyzed using software to identify those spots which are significantly different between the 3 groups. Mass spectrometry was used to identify the proteins and their identity was confirmed with Western blot. RESULTS The highest levels of MMP-2, LDH, and NGAL were seen for the DCDD kidneys, followed by the DNDD kidneys and then LDK. Peroxiredoxin-2, NGAL, and alpha-1-antitrypsin were identified as significantly different between the different types of donor kidneys, and their role and possible therapeutic strategies are discussed. Collagen fragments, albumin, and immunoglobulin were also identified as possible byproducts of the injury and may be useful is assessing the degree of injury. CONCLUSIONS Comparison of the perfusates from the different types of kidneys has allowed us to identify proteins that will be useful in future research into reducing injury in transplant kidneys.

PMID: 29217818 [PubMed - in process]

Outcome and survival of myeloma patients diagnosed 2008-2015. Real world data on 4904 patients from the Swedish Myeloma Registry (SMR).

Sat, 12/09/2017 - 13:45
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Outcome and survival of myeloma patients diagnosed 2008-2015. Real world data on 4904 patients from the Swedish Myeloma Registry (SMR).

Haematologica. 2017 Dec 07;:

Authors: Blimark CH, Turesson I, Genell A, Ahlberg L, Björkstrand B, Carlson K, Forsberg K, Juliusson G, Linder O, Mellqvist UH, Nahi H, Kristinsson SY, Swedish Myeloma Registry

Abstract
Epidemiology and outcome of myeloma is mainly reported from large university centers and collaborative groups and do not represent real world patients. The Swedish Myeloma Registry is a prospective population-based registry documenting characteristics, treatments and outcome in newly diagnosed myeloma, including asymptomatic and localized forms, with the purpose to improve the management and outcome. This report presents information on patients diagnosed between 2008 and 2015, including data on first line treatment up to 2014, with a follow-up until December 2016. We present age-adjusted incidence, patient characteristics at baseline, treatment, response, and survival. Baseline data was available with a 97% coverage in 4,904 patients (median age 71 years, males 70 years, females 73 years, 72% were 65 years or older), and one-year follow-up of 3,558 patients with symptomatic disease (92% of patients initially reported). The age-adjusted incidence was 6.8 myeloma cases per 100 000 inhabitants and year. Among initially symptomatic patients (n=3,988), 77% had osteolytic lesions or compression fractures, 49% had anemia, 18% impaired kidney function, and 13% hypercalcemia. High-dose therapy with autologous stem cell transplantation was given to 77% of patients up to 66 years, and to 22% of patients 66-70 years. In the study period, 68% received bortezomib, thalidomide, and/or lenalidomide as part of the first line treatment, rising from 31% in 2008 to 81% 2014. In MM, the median relative survival of patients 65 years or younger was 7.7 years, and 3.4 years in 66 years and older. Patients diagnosed with myeloma in more recent years were associated with significantly higher rates of complete or very good partial remission (p<0.05), and with a significant higher overall survival with a HR of 0.84 (95% CI 0.77-0.92; p< 0.05). There was small, but significant survival benefit in patients treated in university hospitals (HR 0.93; 95% CI 0.87-0.99, p<0.05). Analysis of progression-free survival has to await collection of additional follow-up data. We here report on a near complete real world population of myeloma patients during an 8-year period, when newer drugs were implemented into standard practice. The overall incidence and median age were both higher than in most previous studies, indicating a more complete coverage of older patients. Myeloma survival in Sweden compare to other large registry studies and responses and survival improved during the study period.

PMID: 29217784 [PubMed - as supplied by publisher]

Compelling Evidence of the Need for Policy Change to Decrease Deceased Donor Kidney Discard in the United States: Waste Not Want Less.

Sat, 12/09/2017 - 13:45
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Compelling Evidence of the Need for Policy Change to Decrease Deceased Donor Kidney Discard in the United States: Waste Not Want Less.

Clin J Am Soc Nephrol. 2017 Dec 07;:

Authors: Kadatz M, Gill JS

PMID: 29217538 [PubMed - as supplied by publisher]

Characteristics and Performance of Unilateral Kidney Transplants from Deceased Donors.

Sat, 12/09/2017 - 13:45
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Characteristics and Performance of Unilateral Kidney Transplants from Deceased Donors.

Clin J Am Soc Nephrol. 2017 Dec 07;:

Authors: Husain SA, Chiles MC, Lee S, Pastan SO, Patzer RE, Tanriover B, Ratner LE, Mohan S

Abstract
BACKGROUND AND OBJECTIVES: The fraction of kidneys procured for transplant that are discarded is rising in the United States. Identifying donors from whom only one kidney was discarded allows us to control for donor traits and better assess reasons for organ discard.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective cohort study using United Network for Organ Sharing Standard Transplant Analysis and Research file data to identify deceased donors from whom two kidneys were procured and at least one was transplanted. Unilateral pairs were defined as kidney pairs from a single donor from whom one kidney was discarded ("unilateral discard") but the other was transplanted ("unilateral transplant"). Organ quality was estimated using the Kidney Donor Risk Index and Kidney Donor Profile Index (KDPI). We compared all-cause graft failure rates for unilateral transplants to those for bilateral transplant Kaplan-Meier methods, and life table methodology was used to evaluate 1-, 2-, 3-, and 5-year survival rates of transplants from bilateral and unilateral donors.
RESULTS: Compared with bilateral donors (i.e., both kidneys transplanted) (n=80,584), unilateral donors (i.e., only one kidney transplanted) (n=7625) had higher mean terminal creatinine (1.3±2.1 mg/dl versus 1.1±0.9 mg/dl) and KDPI (67%±25% versus 42%±27%), were older, and were more likely to have hypertension, diabetes, hepatitis C, terminal stroke, or meet Centers for Disease Control and Prevention high-risk donor criteria. Unilateral discards were primarily attributed to factors expected to be similar in both kidneys from a donor: biopsy findings (22%), no interested recipient (13%), and donor history (7%). Anatomic abnormalities (14%), organ damage (11%), and extended ischemia (6%) accounted for about 30% of discards, but were the commonest reasons among low KDPI kidneys. Among kidneys with KDPI≥60%, there was an incremental difference in allograft survival over time (for unilateral versus bilateral transplants, 1-year survival: 83% versus 87%; 3-year survival: 69% versus 73%; 5-year survival: 51% versus 58%).
CONCLUSIONS: A large number of discarded kidneys were procured from donors whose contralateral kidneys were transplanted with good post-transplant outcomes.

PMID: 29217537 [PubMed - as supplied by publisher]

Pre-transplant AT1R antibodies correlate with early allograft rejection.

Sat, 12/09/2017 - 13:45
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Pre-transplant AT1R antibodies correlate with early allograft rejection.

Transpl Immunol. 2017 Dec 04;:

Authors: Gareau AJ, Wiebe C, Pochinco D, Gibson IW, Ho J, Rush DN, Nickerson PW

Abstract
Studies investigating the potential pathogenic effects of non-HLA antibodies (Ab) have identified Ab against the angiotensin II type 1 receptor (AT1R-Ab) as a risk factor for rejection and kidney graft loss. This study sought to validate the risk of AT1R-Ab for acute rejection and to explore the role of other non-HLA Abs in this capacity. Pre- and post-transplant sera from a cohort of 101 patients (n=453 samples total) were tested for AT1R-Ab and other non-HLA Ab using a commercially available ELISA kit and the Luminex platform, respectively. Patients positive for pre-transplant AT1R-Ab were more likely to develop de novo donor-specific Ab (dnDSA) compared to patients that were negative for AT1R-Ab (28% vs 10%, p=0.027). Pre-transplant positivity for AT1R-Ab was associated with TCMR in the first year post-transplant (p=0.034), but did not predict graft loss independent of dnDSA (p=0.063). AT1R-Ab positivity was significantly associated with positivity for Ab against the endothelin A type 1 receptor (ETAR-Ab) inclusive of all study time points (p=0.0021). Given the high prevalence of AT1R-Ab pre-transplant (20%) and its association with dnDSA and early TCMR, a prospective study to determine if more intense immunosuppression and/or AT1R blockade has an impact on outcomes in these patients is warranted.

PMID: 29217423 [PubMed - as supplied by publisher]

The Transliminal Self: The Ebb and Flow of the Kidney Transplant Experience.

Sat, 12/09/2017 - 13:45
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The Transliminal Self: The Ebb and Flow of the Kidney Transplant Experience.

Qual Health Res. 2017 Dec 01;:1049732317743937

Authors: Bogue Kerr S, Soulière M, Bell L

Abstract
For people with kidney disease, transplantation is considered a better treatment option than dialysis. A kidney transplant does not, however, ensure an illness-free existence. Compared with the wealth of literature produced from a biomedical perspective, there is little qualitative research focused on the young adult transplant experience. This article presents the findings of a phenomenological study exploring young adults' kidney transplant experiences. Using a qualitative phenomenological approach, semidirected interviews were conducted with five people. Analysis of the transcribed interviews revealed that these individuals' kidney transplant experiences were paradoxical in nature: Participants described an existence between sickness and health, self and other, life and death. Consequently, liminality was identified as one of the experience's key elements and used together with the concept of rites of passage in its analysis. To incorporate these experiences, the term transliminal self is proposed.

PMID: 29216809 [PubMed - as supplied by publisher]

Infection in Organ Transplantation.

Sat, 12/09/2017 - 13:45
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Infection in Organ Transplantation.

Am J Transplant. 2017 Apr;17(4):856-879

Authors: Fishman JA

Abstract
The prevention, diagnosis, and management of infectious disease in transplantation are major contributors to improved outcomes in organ transplantation. The risk of serious infections in organ recipients is determined by interactions between the patient's epidemiological exposures and net state of immune suppression. In organ recipients, there is a significant incidence of drug toxicity and a propensity for drug interactions with immunosuppressive agents used to maintain graft function. Thus, every effort must be made to establish specific microbiologic diagnoses to optimize therapy. A timeline can be created to develop a differential diagnosis of infection in transplantation based on common patterns of infectious exposures, immunosuppressive management, and antimicrobial prophylaxis. Application of quantitative molecular microbial assays and advanced antimicrobial therapies have advanced care. Pathogen-specific immunity, genetic polymorphisms in immune responses, and dynamic interactions between the microbiome and the risk of infection are beginning to be explored. The role of infection in the stimulation of alloimmune responses awaits further definition. Major hurdles include the shifting worldwide epidemiology of infections, increasing antimicrobial resistance, suboptimal assays for the microbiologic screening of organ donors, and virus-associated malignancies. Transplant infectious disease remains a key to the clinical and scientific investigation of organ transplantation.

PMID: 28117944 [PubMed - indexed for MEDLINE]

Is the Reluctance for the Implantation of Right Kidneys Justified: Reply.

Sat, 12/09/2017 - 13:45
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Is the Reluctance for the Implantation of Right Kidneys Justified: Reply.

World J Surg. 2017 01;41(1):326-327

Authors: Özdemir-van Brunschot DM, Warlé MC

PMID: 27853814 [PubMed - indexed for MEDLINE]

Anuria after renal graft biopsy: Multidisciplinary intervention.

Sat, 12/09/2017 - 13:45
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Anuria after renal graft biopsy: Multidisciplinary intervention.

Nefrologia. 2016 Jul-Aug;36(4):456-7

Authors: Torres Sánchez MJ, Galindo Sacristán P, Pérez Marfil A, de Teresa Alguacil J, Barroso Martín FJ, Osorio Moratalla JM, Alcázar Romero PP, Martínez Morcillo A, Vicente Prados J, Aparicio Gómez JA, Osuna Ortega A

PMID: 26857206 [PubMed - indexed for MEDLINE]

Getting More Organs for Transplantation.

Sat, 12/09/2017 - 13:45
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Getting More Organs for Transplantation.

Am Econ Rev. 2014 May;104(5):425-30

Authors: Kessler JB, Roth AE

PMID: 29115805 [PubMed - indexed for MEDLINE]

New Challenges in Multihospital Kidney Exchange.

Sat, 12/09/2017 - 13:45
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New Challenges in Multihospital Kidney Exchange.

Am Econ Rev. 2012 May;102(3):354-9

Authors: Ashlagi I, Roth AE

PMID: 29115794 [PubMed - indexed for MEDLINE]

Efficient Kidney Exchange: Coincidence of Wants in Markets with Compatibility-Based Preferences.

Sat, 12/09/2017 - 13:45
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Efficient Kidney Exchange: Coincidence of Wants in Markets with Compatibility-Based Preferences.

Am Econ Rev. 2007 Jun;97(3):828-51

Authors: Roth AE, Sönmez T, Ünver U

Abstract
Patients needing kidney transplants may have donors who cannot donate to them because of blood or tissue incompatibility. Incompatible patient-donor pairs can exchange donor kidneys with other pairs only when there is a "double coincidence of wants." Developing infrastructure to perform three-way as well as two-way exchanges will have a substantial effect on the number of transplants that can be arranged. Larger than three-way exchanges have less impact on efficiency. In a general model of type-compatible exchanges, the size of the largest exchanges required to achieve efficiency equals the number of types.

PMID: 29135211 [PubMed - indexed for MEDLINE]

A Kidney Exchange Clearinghouse in New England.

Sat, 12/09/2017 - 13:45
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A Kidney Exchange Clearinghouse in New England.

Am Econ Rev. 2005 May;95(2):376-80

Authors: Roth AE, Sönmez T, Ünver MU

PMID: 29125723 [PubMed - indexed for MEDLINE]

Kidney Transplantation in Patients with Atypical Hemolytic Uremic Syndrome due to Complement Factor H Deficiency: Impact of Liver Transplantation.

Fri, 12/08/2017 - 13:45

Kidney Transplantation in Patients with Atypical Hemolytic Uremic Syndrome due to Complement Factor H Deficiency: Impact of Liver Transplantation.

J Korean Med Sci. 2018 Jan 01;33(1):e4

Authors: Kim S, Park E, Min SI, Yi NJ, Ha J, Ha IS, Cheong HI, Kang HG

Abstract
BACKGROUND: Atypical hemolytic uremic syndrome (aHUS) is a rare disease that is often associated with genetic defects. Mutations of complement factor H (CFH) are the most common genetic defects that cause aHUS and often result in end-stage renal disease. Since CFH is mainly produced in the liver, liver transplantation (LT) has been performed in patients with defective CFH.
METHODS: The clinical courses of four kidney allograft recipients who lost their native kidney functions due to aHUS associated with a CFH mutation were reviewed.
RESULTS: Subject A underwent kidney transplantation (KT) twice, aHUS recurred and the allograft kidney failed within a few years. Subject B received a KT and soon experienced a recurrence of aHUS coinciding with infection. Her allograft kidney function has worsened, and she remains on plasma infusion therapy. Subject C underwent LT followed by KT. She is doing well without plasma infusion therapy after combined LT-KT for 3 years. Subject D received KT following LT and is now recurrence-free from aHUS.
CONCLUSION: In patients with aHUS associated with a CFH mutation, KT without LT was complicated with a recurrence of aHUS, which might lead to allograft loss. Conversely, LT was successful in preventing the recurrence of aHUS and thus might be another option for a recurrence-free life for aHUS patients associated with CFH mutation.

PMID: 29215813 [PubMed - in process]

Simultaneous Pancreas and Kidney Transplantation is Associated With Inferior Long-Term Outcomes in African Americans.

Fri, 12/08/2017 - 13:45

Simultaneous Pancreas and Kidney Transplantation is Associated With Inferior Long-Term Outcomes in African Americans.

Pancreas. 2017 Dec 05;:

Authors: Brooks JT, Liu R, Oliver M, DeLeonibus A, Mei J, White D, Siskind E, Ortiz J

Abstract
OBJECTIVES: Simultaneous pancreas and kidney transplant (SPK) is the most effective treatment for patients with type 1 diabetes mellitus and renal failure. However, the effect of ethnicity on SPK outcomes is not well understood.
METHODS: We studied the influence of recipient ethnicity on SPK using the United Network for Organ Sharing database. A retrospective review of 20,196 SPK patients from 1989 to 2014 was performed. The recipients were divided into 4 groups: 15,833 whites (78.40%), 2708 African Americans (AA) (14.39%), 1456 Hispanics (7.21%), and 199 Asians (0.99%).
RESULTS: Hispanics and Asians experienced the best overall graft and patient outcomes. Both groups demonstrated significantly superior graft and patient survival rates compared with whites at 1, 3, 5, 10, and 15 years (all P < 0.0001). African Americans experienced significantly superior 1- and 3-year patient survival compared with whites (both P < 0.0001). African Americans also experienced significantly superior 1-year kidney and pancreas graft survival compared with whites (P < 0.0001). However, AA experienced significantly inferior patient and allograft outcomes for all other time points compared with whites.
CONCLUSIONS: Based on United Network for Organ Sharing data from 1989 to 2014, AA have worse long-term patient and graft survival rates compared with whites, Hispanics, and Asians undergoing SPK.

PMID: 29215537 [PubMed - as supplied by publisher]

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