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Publications

Combination of everolimus with calcineurin inhibitor medication resulted in post-transplant haemolytic uraemic syndrome in lung transplant recipients--a case series

MedWorm Lung Transplant - Fri, 09/16/2011 - 03:00
Conclusions. Our data should raise the awareness of post-transplant HUS in lung transplant recipients. Post-transplant HUS is a rare disease, but it is a serious cause of acute renal failure in lung transplant recipients treated with a combination of everolimus and calcineurin inhibitors. (Source: Nephrology Dialysis Transplantation)

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Categories: Publications

Multiple extramedullary relapses without bone marrow involvement after second allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia

MedWorm Lung Transplant - Fri, 09/16/2011 - 03:00
We report a case of diffuse EMR of AML without BM involvement after a second allogeneic HSCT. (Source: Pediatric Transplantation)
Categories: Publications

Autoantibody formation in human and rat studies of chronic rejection and primary graft dysfunction.

MedWorm Lung Transplant - Fri, 09/16/2011 - 03:00
Authors: Wilkes DS Abstract Lung transplantation is considered a definitive treatment for many lung diseases. However, rejection and other pathologic entities are major causes of morbidity and mortality for lung transplant recipients. Primary graft dysfunction (PGD) and obliterative bronchiolitis (OB) are the leading causes of early and late mortality, respectively. While the immune basis of PGD has not been clearly defined, evidence is emerging about roles for autoantibodies in this process. Similarly, the pathogenesis of OB has been linked recently to autoimmunity. This review will highlight the current understanding of autoantibodies in PGD and OB post lung transplantation. PMID: 21925897 [PubMed - as supplied by publisher] (Source: Seminars in Immunology)
Categories: Publications

Estrogen treatment may help reverse severe pulmonary hypertension

MedWorm Lung Transplant - Thu, 09/15/2011 - 15:35
UCLA researchers have found that the hormone estrogen may help reverse advanced pulmonary hypertension, a rare and serious condition that affects 2 million to 3 million individuals in the U.S., mostly women, and can lead to heart failure.   The condition causes a progressive increase in blood pressure in the main pulmonary artery, which originates in the heart's right ventricle and delivers blood to the lungs. The rise in pressure impairs heart function by enlarging the right ventricle, potentially leading to heart failure.   Published in the Sept. 15 issue of the American Journal of Respiratory and Critical Care Medicine, the preclinical study shows that in rats, estrogen treatment can reverse the progression of pulmonary hypertension to heart failure and can restore lung a...
Categories: Publications

The intensity of bronchiolar epithelial cell injury caused by an alloimmune response is ameliorated by transbronchial human interleukin-10 gene transfer in a rat model of lung transplantation

MedWorm Lung Transplant - Thu, 09/15/2011 - 14:53
Abstract  The aim of the present study was to determine whether the intensity of bronchiolar epithelial cell injury is ameliorated by transbronchial human IL-10 (hIL-10) gene transfer in a rat model of lung allograft rejection. The left lung was extracted from a donor Brown Norway rat and transbronchially instilled with encoding hIL-10 (IL-10 group) or β-galactosidase (control group). The lung graft was then transplanted into a Lewis rat and harvested on day 6 after transplantation. The allografts were histologically examined and all bronchioles in the slides were assigned one of three grades according to the intensity of epithelial cell loss. The distribution of the grades was significantly different between the two groups, and the epithelial cell injury was significantly ...
Categories: Publications

Low-Level, Chronic Hematuria in Young Signals Later ESRD

MedWorm Kidney Transplant - Tue, 08/16/2011 - 20:00
Persistent, trace amounts of blood in the urine in teens and young adults may serve as a marker for future end-stage renal disease, according to a large-scale, retrospective study.
Categories: Publications

Agave From Root Cuttings

MedWorm Lung Transplant - Sun, 08/14/2011 - 11:47
Last February, we had a very unusual hard freeze. It killed a lot of plants. The prior year, I had gotten an agave from a local nursery. It was a nice specimen, about 12 inches wide; it cost $25. In the freeze, it died. So I removed all the dead matter above ground. In the springtime, I watered it sparingly. After a couple of months, there was no visible growth. One weekend, I went and bought a plant to replace it. The new plant is a Dasylirion wheeleri, aka sotol, or desert spoon. These things grow in the mountains, where it actually snows sometimes. Ought to be able to tolerate a freeze or two. When I dug a hole for the sotol, I found a lot of thick, moist, viable-looking root from the agave. Somewhere, sometime, I had read about propagation from root cuttings. So I used some cactus pott...
Categories: Publications

Readers Not Against Paying for Kidneys

MedWorm Kidney Transplant - Fri, 08/12/2011 - 21:50
Eight out of 10 of the respondents to a ALLMedPage Today poll agreed that people should be paid for live-donor kidneys.
Categories: Publications

HLA Desensitizing Ups Survival in Kidney Transplant

MedWorm Kidney Transplant - Fri, 07/29/2011 - 19:37
Survival after kidney transplantation improved significantly in patients who underwent desensitization involving depletion of donor-specific anti-HLA antibodies, data from an 11-year clinical experience showed.
Categories: Publications

Mismatch Matters for Kids' Kidney Transplants

MedWorm Kidney Transplant - Thu, 07/21/2011 - 18:30
Antigen incompatibility hurts pediatric kidney transplant outcomes, but may often be unavoidable unless changes are made to the organ allocation system, researchers suggested.
Categories: Publications

ADA: Tight Control No Help After Renal Treatment

MedWorm Kidney Transplant - Tue, 06/28/2011 - 16:00
SAN DIEGO -- Tight glucose control early after kidney transplantation doesn't improve graft success, researchers found.
Categories: Publications

CMS to Keep Current Payment Policy for ESAs

MedWorm Kidney Transplant - Sun, 06/19/2011 - 13:30
WASHINGTON -- Officials with the Centers for Medicare and Medicaid Services announced it won't change its payment policy on erythropoiesis stimulating agents used to treat anemia in kidney patients.
Categories: Publications

FDA Okays New Kidney Transplant Drug

MedWorm Kidney Transplant - Thu, 06/16/2011 - 19:00
WASHINGTON -- The FDA has approved belatacept (Nulojix) for use with other immunosuppressants in preventing organ rejection in kidney transplant patients.
Categories: Publications

Revised Article-Lung Transplant

MedWorm Lung Transplant - Tue, 05/24/2011 - 23:00
A lung transplant is surgery to remove a person's diseased lung and replace it with a healthy lung from a deceased donor. (Source: National Heart, Lung, and Blood Institute Health Topics)
Categories: Publications

Level of tumor protein indicates chances cancer will spread

MedWorm Liver Transplant - Wed, 02/02/2011 - 00:44
Contact: Robert Bock or Marianne Glass Miller 301-496-5133 Level of tumor protein indicates chances cancer will spread NIH researchers seek to develop test to guide treatment Researchers at the National Institutes of Health and the University of Hong Kong have discovered that high levels of a particular protein in cancer cells are a reliable indicator that a cancer will spread. By measuring the protein’s genetic material in tumors that had been surgically removed from patients, along with measuring the genetic material from surrounding tissue, the researchers could predict at least 90 percent of the time whether a cancer would spread within two years. The findings raise the long term possibilities of new tests to gauge the likelihood that a cancer will spread and, ultimately, of a t...

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Categories: Publications

Revised Article-Total Artificial Heart

MedWorm Lung Transplant - Tue, 06/22/2010 - 23:00
A total artificial heart (TAH) is a device that replaces the two lower chambers of the heart. (Source: National Heart, Lung, and Blood Institute Health Topics)
Categories: Publications

Novartis kidney cancer drug clears key hurdle

MedWorm Lung Transplant - Thu, 02/28/2008 - 15:43
Everolimus (RAD001) significantly extends progression-free survival in advanced kidney cancer patients after failure of other targeted therapy  Outstanding interim results cause independent data monitoring committee to immediately share findings; patients on placebo to be offered everolimus  Everolimus (RAD001) tablet, taken once daily, demonstrated highly effective anti-tumor activity through continuous targeted inhibition of mTOR  Results of RECORD-1 trial address unmet medical need in renal cell cancer with worldwide regulatory filings planned for second half of 2008  Complete results to be submitted as late-breaking abstract for presentation at the American Society of Clinical Oncology meeting  Basel, February 28, 2008 — An independent data ...

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Categories: Publications

Liver Donor Policy To Change

MedWorm Liver Transplant - Fri, 06/25/1999 - 01:00
Sickest Patients To Receive Transplants First (Source: Health News: CBSNews.com)
Categories: Publications

Revised Article-Heart Transplant

MedWorm Lung Transplant - Wed, 12/31/1969 - 23:00
A heart transplant is surgery to remove a diseased heart and replace it with a healthy heart from a deceased donor. (Source: National Heart, Lung, and Blood Institute Health Topics)
Categories: Publications

Revised Article-Blood and Marrow Stem Cell Transplant

MedWorm Lung Transplant - Wed, 12/31/1969 - 23:00
A blood and marrow stem cell transplant is a procedure that replaces a person's faulty stem cells with healthy ones. (Source: National Heart, Lung, and Blood Institute Health Topics)
Categories: Publications

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