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Publications

Lung transplantation in coal workers pneumoconiosis.

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
Authors: Diaz-Guzman E, Zwischenberger JB, Hoopes CW PMID: 22045888 [PubMed - in process] (Source: Chest)
Categories: Publications

A genetic polymorphism in the CAV1 gene associates with the development of bronchiolitis obliterans syndrome after lung transplantation

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
A genetic polymorphism and a consequential increase in protein serum levels contribute to the development of bronchiolitis obliterans syndrome after lung transplantation. (Source: Fibrogenesis and Tissue Repair)
Categories: Publications

Stent Angioplasty for a Kink in the Pulmonary Artery Anastomosis Soon After Living-Donor Lobar Lung Transplantation [CASE REPORTS]

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
Herein, we report a case of stent angioplasty for a kink in the pulmonary artery (PA) anastomosis soon after living-donor lobar lung transplantation (LDLLT). A 64-year-old man with idiopathic pulmonary fibrosis underwent bilateral LDLLT with lung donations from his daughters. After reperfusion, the left PA anastomosis showed a kink, which could not be corrected completely during surgery. Due to the kink in the left PA, and the relatively small donor grafts, the patient required extracorporeal membrane oxygenation) after LDLLT. Approximately 24 hours after reperfusion, stent angioplasty was performed, resulting in the patient being successfully weaned from extracorporeal membrane oxygenation on postoperative day 4. (Source: The Annals of Thoracic Surgery)
Categories: Publications

Allograft Rejection in Patients Supported With Continuous-Flow Left Ventricular Assist Devices [ORIGINAL ARTICLES: ADULT CARDIAC]

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
Conclusions Patients with continuous-flow LVADs have similar overall rejection rates and a reduced rate of clinically relevant rejection compared with patients with pulsatile-flow LVADs during the first year after transplantation. Although there is theoretical concern that nonphysiologic, nonpulsatile flow could alter the neurohormonal profile of patients in heart failure, we are encouraged that the type of LVAD circulation does not influence posttransplantation allograft survival. (Source: The Annals of Thoracic Surgery)

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Categories: Publications

Adenosine A2A Agonist Improves Lung Function During Ex Vivo Lung Perfusion [ORIGINAL ARTICLES: GENERAL THORACIC]

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
Conclusions Combined use of adenosine A2A agonist and EVLP significantly attenuates the inflammatory response in acutely injured lungs after IR and enhances pulmonary function. This combination may improve donor lung quality and could increase the donor lung pool for transplantation. (Source: The Annals of Thoracic Surgery)
Categories: Publications

Geographic Distance Between Donor and Recipient Does Not Influence Outcomes After Lung Transplantation [ORIGINAL ARTICLES: GENERAL THORACIC]

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
Conclusions With appropriate donor selection, moderately long geographic distance (average ischemic time < 6 hours) between the donor and recipient is not associated with the development of BOS or increased death after lung transplantation. By placing less emphasis on distance, more donors could potentially be used to expand the donor pool. (Source: The Annals of Thoracic Surgery)
Categories: Publications

Successful Surgical Treatment of a Posttransplantation Bronchovascular Fistula Involving the Pulmonary Vein [CASE REPORTS]

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
We describe the case of successful surgical treatment of bronchovascular fistula of the left upper pulmonary vein and the left main bronchus. (Source: The Annals of Thoracic Surgery)
Categories: Publications

Proliferating Bronchial Webs After Lung Transplantation [CASE REPORTS]

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
This case details the decline in lung function due to bronchial webs in a lung transplant recipient. The decline occurred 2 years after transplantation and, despite therapy, the webs, which had an inflammatory component, became treatment resistant. We outline the pathological findings and management strategies used, discuss the evidence in the literature, and offer possible causes for these unusual clinical findings. (Source: The Annals of Thoracic Surgery)
Categories: Publications

The role of neuromuscular blocking drugs in early severe acute respiratory distress syndrome.

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
CONCLUSIONS: Treatment in early severe ARDS with the NMBA, cisatracurium, for 48 hr was associated with lower adjusted 90-day mortality. It was also associated with decreased morbidity, which included increased ventilator-free days, increased ICU-free days, and increased organ failure-free days. These benefits occurred without increasing the incidence of ICU-acquired weakness. PMID: 22042702 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)

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Categories: Publications

Periostitis secondary to prolonged voriconazole therapy in a lung transplant recipient.

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
This article reports a case of perostitis deformans in a lung transplantation patient taking the fluoride-containing medication voriconazole, a relatively new and potent anti-fungal. The patient had a normal range of motion in all joints and a normal gait. On radiographs at presentation, multifocal areas of periostitis were visualized involving the left-hand first, second, and third proximal phalanx shafts. Similar periostitis was present on the left-hand third, fourth, and fifth middle phalanx shafts. Plain radiographs of the right hand also demonstrated multifocal periostitis of the third and fourth proximal and middle phalanges. Aggressive periostitis at the level of the right fourth proximal and middle phalanges was also present. Given her long-term treatment with voriconazole and a pr...
Categories: Publications

Organ Donation in Belgium 2010: An Increase of Combined Organ Transplants and Living Donor Liver Transplantations

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
This issue of Transplantation Proceedings contains a selected number of studies presented at the 18th annual Belgian Transplantation Society (BTS) meeting that was held on March 24, 2011 in Brussels. As usual in addition to the scientific program, the BTS annual meeting reviewed the donation trends from 1990 to 2010. Last year, 521 potential deceased organ donors were referred to Belgian transplantation centres (51 potential donors pmp), but only 50% of them became effective organ donors, resulting in 263 effective deceased organ donors (25.3 organ donors pmp) with a mean age of 50 years (range: 1–89 years). Medical contraindications constituted the major reason for non-procurement in roughtly 30% of cases, whereas we recorded a slight decrease in family refusal (12% of cases). The Belgi...
Categories: Publications

The Need for a New Animal Model for Chronic Rejection After Lung Transplantation

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
Abstract: The single most important cause of late mortality after lung transplantation is obliterative bronchiolitis (OB), clinically characterized by a decrease in lung function and morphologically by characteristic changes. Recently, new insights into its pathogenesis have been acquired: risk factors have been identified and the use of azithromycin showed a dichotomy with at least 2 different phenotypes of bronchiolitis obliterans syndrome (BOS). It is clear that a good animal model is indispensable to further dissect and unravel the pathogenesis of BOS. Many animal models have been developed to study BOS but, so far, none of these models truly mimics the human situation. Looking at the definition of BOS, a good animal model implies histological OB lesions, possibility to measure lung fu...
Categories: Publications

Acute urine retention induced by ceftriaxone.

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
Authors: Akl KF, Masri AT, Hjazeen MM Abstract Ceftriaxone is known to cause biliary pseudolithiasis and, rarely, nephrolithiasis. When used in neonates receiving intravenous calcium, fatal lung and kidney calcifications occur. There is no satisfactory explanation for the pseudolithiasis, and the mechanism of stone formation remains unknown. Herein, we report a child with acute urinary retention (AUR) secondary to ceftriaxone therapy. The AUR developed on the second hospital day. The urinary excretion of uric acid was elevated. In retrospect, there was a positive paternal family history of gout and stones. A positive family history of gout or stones is a pointer to the possibility of AUR or urolithiasis in patients on treatment with ceftriaxone. If urinary symptoms develop, it is w...
Categories: Publications

The Impact of Extracorporeal Membrane Oxygenation on Survival in Pediatric Patients With Respiratory and Heart Failure: Review of Our Experience

MedWorm Lung Transplant - Tue, 11/01/2011 - 03:00
AbstractExtracorporeal membrane oxygenation (ECMO) is widely used for circulatory support in pediatric cardiac patients with low cardiac output and hypoxemia. We retrospectively evaluated the efficacy of ECMO support for respiratory and heart failure in infants and children. From April 2002 to February 2011, 14 patients aged 19 days to 20 years old (average 44 months), with body weight 2.6 kg to 71 kg (median 14.1 kg), underwent ECMO support for failing cardiac function, hypoxemia, and low cardiac output syndrome. In 12 patients, ECMO was introduced after operation for congenital heart disease (four with complete repair including Fontan circulation, and eight with palliative repair). In one patient, ECMO was introduced after partial pulmonary resection for congenital cystic adenomato...

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Categories: Publications

Age No Barrier to Live Kidney Donation

MedWorm Kidney Transplant - Mon, 10/31/2011 - 19:16
Healthy, older seniors can act as living kidney donors, with overall survival among recipients similar to that seen with younger donors, a study suggested.
Categories: Publications

Intra-operative fitting study of the PediPump ventricular assist device

MedWorm Lung Transplant - Mon, 10/31/2011 - 03:00
Issues related to anatomic fit of implantable ventricular assist devices (VADs) are particularly important during the development of devices intended for implantation in pediatric patients or in patients with a small body surface area (BSA) of (Source: The Journal of Heart and Lung Transplantation)
Categories: Publications

UK HealthCare surgeons are first to perform novel procedures prior to transplant

MedWorm Lung Transplant - Mon, 10/31/2011 - 03:00
(University of Kentucky) Surgeons at UK HealthCare recently became the first ever to perform two specific procedures together as a bridge to lung transplantation. (Source: EurekAlert! - Medicine and Health)
Categories: Publications

Physiologic Effect and Safety of the Pumpless Extracorporeal Interventional Lung Assist System in Patients With Acute Respiratory Failure—A Pilot Study

MedWorm Lung Transplant - Mon, 10/31/2011 - 03:00
AbstractInterventional lung assist (iLA) effectively reduces CO2 tension and permits protective lung ventilation in patients with acute respiratory distress syndrome. However, there is little experience in using iLA in acute respiratory failure from various causes and no experience for small body sizes such as Asian patients. We evaluated the physiologic effect and safety of the iLA device in patients with acute respiratory failure from various causes. We enrolled 11 consecutive patients with severe respiratory failure from various causes. Wire‐enforced cannulae (13–15 Fr) were inserted under ultrasound guidance and connected to iLA. Arterial blood gas analysis, ventilator parameters, hemodynamic parameter, and adverse events were recorded serially. During the first 24 h of iLA use, ...
Categories: Publications

[Lung transplantation in Hungary (1996-2011)].

MedWorm Lung Transplant - Sun, 10/30/2011 - 03:00
Authors: Strausz J Abstract The 15 years history of lung transplantation in Hungary shows the medical, political and social characteristics of this period. The barely determined, open-ended legal, financial and ethical framework of transplantation has stayed nowadays in the same position. The Hungarian State Audit Office has also noted these problems. Joining of Hungary to Eurotransplant will beneficially influence the whole procedure. Orv. Hetil., 2011, 152, 1772-1774. PMID: 21997582 [PubMed - in process] (Source: Orvosi Hetilap)
Categories: Publications

Idiopathic Pulmonary Fibrosis Survival Predicted With Blood Proteins

MedWorm Lung Transplant - Fri, 10/28/2011 - 12:00
According to investigators at the University of Pittsburgh School of Medicine and Centocor R&D, a group of blood proteins can foresee which patients with idiopathic pulmonary fibrosis (IPF) - a progressive lung disease - are more likely to die within two years or live at least five years. The discoveries could assist doctors in deciding which patients require a lung transplantation urgently from those who can wait longer. The findings were published online last week in the American Journal of Respiratory and Critical Care Medicine... (Source: Health News from Medical News Today)
Categories: Publications

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